Analysis Tools
hematopoietic system
| N |
• thymus numbers are similar to controls
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Allele Symbol Allele Name Allele ID |
Cbx4tm1.1Gxu targeted mutation 1.1, Guo-Liang Xu MGI:5489931 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• thymus numbers are similar to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• expression analysis indicates a defect in the maturation of both medullary and cortical epithelial cells
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• limited thymic epithelial architecture quickly deteriorates in postnatal mice with discrete cortical and medullary structures no longer seen at 3 weeks of age
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• severe
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• expression analysis indicates impaired proliferation of developing epithelial cells
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• the double negative population is over-represented and composed primarily of B220+ B lineage cells instead of T lineage precursors
• however, the absolute number of B lineage cells in the thymus is similar to controls
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• the T cell compartment in the periphery is never fully established in adult mice
• the CD3+ population in the spleen is small
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• markedly reduced in proportion in the thymus at 3 weeks of age
• barely detectable at 6 weeks of age
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• expression analysis indicates a defect in the maturation of both medullary and cortical epithelial cells
|
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• limited thymic epithelial architecture quickly deteriorates in postnatal mice with discrete cortical and medullary structures no longer seen at 3 weeks of age
|
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• severe
|
|
• expression analysis indicates impaired proliferation of developing epithelial cells
|
|
• the double negative population is over-represented and composed primarily of B220+ B lineage cells instead of T lineage precursors
• however, the absolute number of B lineage cells in the thymus is similar to controls
|
|
• markedly reduced in proportion in the thymus at 3 weeks of age
• barely detectable at 6 weeks of age
|
|
• the T cell compartment in the periphery is never fully established in adult mice
• the CD3+ population in the spleen is small
|
|
• expression analysis indicates a defect in the maturation of both medullary and cortical epithelial cells
|
|
• limited thymic epithelial architecture quickly deteriorates in postnatal mice with discrete cortical and medullary structures no longer seen at 3 weeks of age
|
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• severe
|
|
• expression analysis indicates impaired proliferation of developing epithelial cells
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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