Phenotypes associated with this allele

• Allele Symbol: Cbx4^tm1.1Gxu
• Allele Name: targeted mutation 1.1, Guo-Liang Xu
• Allele ID: MGI:5489931
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cbx4^tm1.1Gxu/Cbx4^tm1.1Gxu Tg(Lck-cre)#Zhu/0	involves: 129S2/SvPas * C57BL/6 * SJL/J	MGI:5489935
cn2	Cbx4^tm1.1Gxu/Cbx4^tm1.2Gxu Tg(Foxn1-cre)1Tbo/0	involves: 129S2/SvPas * C57BL/6J	MGI:5489934

Genotype
MGI:5489935

cn1

• Allelic Composition: Cbx4^tm1.1Gxu/Cbx4^tm1.1Gxu; Tg(Lck-cre)#Zhu/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:194053 )

N • thymus numbers are similar to controls

Genotype
MGI:5489934

cn2

• Allelic Composition: Cbx4^tm1.1Gxu/Cbx4^tm1.2Gxu; Tg(Foxn1-cre)1Tbo/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

hematopoietic system

abnormal thymus development ( J:194053 )

• expression analysis indicates a defect in the maturation of both medullary and cortical epithelial cells

thymus atrophy ( J:194053 )

• limited thymic epithelial architecture quickly deteriorates in postnatal mice with discrete cortical and medullary structures no longer seen at 3 weeks of age

thymus hypoplasia ( J:194053 )

• severe

abnormal thymus physiology ( J:194053 )

• expression analysis indicates impaired proliferation of developing epithelial cells

abnormal lymphopoiesis ( J:194053 )

• the double negative population is over-represented and composed primarily of B220+ B lineage cells instead of T lineage precursors

• however, the absolute number of B lineage cells in the thymus is similar to controls

decreased T cell number ( J:194053 )

• the T cell compartment in the periphery is never fully established in adult mice

• the CD3+ population in the spleen is small

decreased double-positive T cell number ( J:194053 )

• markedly reduced in proportion in the thymus at 3 weeks of age

• barely detectable at 6 weeks of age

immune system

abnormal thymus development ( J:194053 )

• expression analysis indicates a defect in the maturation of both medullary and cortical epithelial cells

thymus atrophy ( J:194053 )

• limited thymic epithelial architecture quickly deteriorates in postnatal mice with discrete cortical and medullary structures no longer seen at 3 weeks of age

thymus hypoplasia ( J:194053 )

• severe

abnormal thymus physiology ( J:194053 )

• expression analysis indicates impaired proliferation of developing epithelial cells

abnormal lymphopoiesis ( J:194053 )

• the double negative population is over-represented and composed primarily of B220+ B lineage cells instead of T lineage precursors

• however, the absolute number of B lineage cells in the thymus is similar to controls

decreased double-positive T cell number ( J:194053 )

• markedly reduced in proportion in the thymus at 3 weeks of age

• barely detectable at 6 weeks of age

decreased T cell number ( J:194053 )

• the T cell compartment in the periphery is never fully established in adult mice

• the CD3+ population in the spleen is small

endocrine/exocrine glands

abnormal thymus development ( J:194053 )

• expression analysis indicates a defect in the maturation of both medullary and cortical epithelial cells

thymus atrophy ( J:194053 )

• limited thymic epithelial architecture quickly deteriorates in postnatal mice with discrete cortical and medullary structures no longer seen at 3 weeks of age

thymus hypoplasia ( J:194053 )

• severe

abnormal thymus physiology ( J:194053 )

• expression analysis indicates impaired proliferation of developing epithelial cells