All Phenotypes Gja8<R205G> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gja8^R205G
Arg205Gly
MGI:5489751

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gja8^R205G/Gja8^R205G	B6.Cg-Gja8^R205G	MGI:5489760
hm2	Gja8^R205G/Gja8^R205G	CWXS/Agl-Gja8^R205G	MGI:5490033
hm3	Gja8^R205G/Gja8^R205G	involves: 129S4/SvJae * CWD/LeAgl * SJL/J	MGI:5489763
ht4	Gja8^R205G/Gja8⁺	B6.Cg-Gja8^R205G	MGI:5489759
ht5	Gja8^R205G/Gja8⁺	CWXS/Agl-Gja8^R205G	MGI:5490032
ht6	Gja8^R205G/Gja8^tm1Scr	involves: 129S1/Sv * 129X1/SvJ * CWD/LeAgl * SJL/J	MGI:5489761
cx7	Gja3^tm1Scr/Gja3^tm1Scr Gja8^R205G/Gja8^R205G	involves: 129S4/SvJae * CWD/LeAgl * SJL/J	MGI:5489762
ot8	Gja8^R205G/?	involves: CWD/LeAgl * SJL/J	MGI:5489764

Allelic Composition	Gja8^R205G/Gja8^R205G
Genetic Background	B6.Cg-Gja8^R205G

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^R205G mutation (1 available); any Gja8 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Dense nuclear cataracts in Gja8^R205G/Gja8^R205G and Gja8^R205G/Gja8^R205G Gja3^tm1Scr/Gja3^tm1Scr mice but degenerating peripheral lens fibers only in Gja8^R205G/Gja8^R205G mice

vision/eye

lens vacuoles ( J:195727 )

• aberrant vacuole-like structures in the lens periphery

nuclear cataract ( J:195727 )

• dense

small lens ( J:195727 )

microphthalmia ( J:195727 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 1 multiple types		DOID:0110231	OMIM:116200	J:195727

Allelic Composition	Gja8^R205G/Gja8^R205G
Genetic Background	CWXS/Agl-Gja8^R205G

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^R205G mutation (1 available); any Gja8 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Dense nuclear cataracts in heterozygous and homozygous Gja8^R205G mice and microphthalmia in homozygotes

vision/eye

nuclear cataract ( J:195727 )

• dense

microphthalmia ( J:195727 )

Allelic Composition	Gja8^R205G/Gja8^R205G
Genetic Background	involves: 129S4/SvJae * CWD/LeAgl * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^R205G mutation (1 available); any Gja8 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

lens vacuoles ( J:195727 )

• aberrant vacuole-like structures or enlarged extracellular spaces in the peripheral regions

abnormal lens fiber morphology ( J:195727 )

• severely disrupted peripheral fiber cell organization with vacuoles and fiber degeneration

nuclear cataract ( J:195727 )

• dense

Allelic Composition	Gja8^R205G/Gja8⁺
Genetic Background	B6.Cg-Gja8^R205G

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^R205G mutation (1 available); any Gja8 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

nuclear cataract ( J:195727 )

small lens ( J:195727 )

• slightly

Allelic Composition	Gja8^R205G/Gja8⁺
Genetic Background	CWXS/Agl-Gja8^R205G

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^R205G mutation (1 available); any Gja8 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Dense nuclear cataracts in heterozygous and homozygous Gja8^R205G mice and microphthalmia in homozygotes

vision/eye

nuclear cataract ( J:195727 )

• dense

Allelic Composition	Gja8^R205G/Gja8^tm1Scr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CWD/LeAgl * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^R205G mutation (1 available); any Gja8 mutation (31 available)
Gja8^tm1Scr mutation (0 available); any Gja8 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Microphthalmia and small lenses with dense nuclear cataracts in Gja8^R205G/Gja8^tm1Scr mice

vision/eye

nuclear cataract ( J:195727 )

• dense

microphthalmia ( J:195727 )

Allelic Composition	Gja3^tm1Scr/Gja3^tm1Scr Gja8^R205G/Gja8^R205G
Genetic Background	involves: 129S4/SvJae * CWD/LeAgl * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3^tm1Scr mutation (0 available); any Gja3 mutation (18 available)
Gja8^R205G mutation (1 available); any Gja8 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Dense nuclear cataracts in Gja8^R205G/Gja8^R205G and Gja8^R205G/Gja8^R205G Gja3^tm1Scr/Gja3^tm1Scr mice but degenerating peripheral lens fibers only in Gja8^R205G/Gja8^R205G mice

vision/eye

vision/eye phenotype ( J:195727 )

N	• mice exhibit normal lens periphery and lens fiber unlike in Gja8^Nm2249 homozygotes

nuclear cataract ( J:195727 )

• dense

Allelic Composition	Gja8^R205G/?
Genetic Background	involves: CWD/LeAgl * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^R205G mutation (1 available); any Gja8 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:156373 )

• fetal

microphthalmia ( J:156373 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24