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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm1(H1-RNAi:Tmsb4x)Prri
targeted mutation 1, Paul Riley
MGI:5487445
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hprt1tm1(H1-RNAi:Tmsb4x)Prri/Hprt1+
Tg(Tek-cre)1Ywa/0 		involves: C57BL/6 * SJL MGI:5487451


Genotype
MGI:5487451
cn1
Allelic
Composition		 Hprt1tm1(H1-RNAi:Tmsb4x)Prri/Hprt1+
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(H1-RNAi:Tmsb4x)Prri mutation (0 available); any Hprt1 mutation (1274 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:195902 )
• fewer than expected mice are recovered between E10.5 and P1
embryonic lethality during organogenesis, incomplete penetrance ( J:195902 )
• fewer than expected mice are recovered between E10.5 and P1

cardiovascular system
abnormal blood vessel morphology ( J:195902 )
• blood vessel walls exhibit reduced recruitment of mural cells compared to in control mice
internal hemorrhage ( J:195902 )
• in the coelomic cavity in some mice at E10.5
hemopericardium ( J:195902 )
• in some mice at E10.5
intracranial hemorrhage ( J:195902 )
• in some mice at E10.5

homeostasis/metabolism
hemopericardium ( J:195902 )
• in some mice at E10.5

nervous system
intracranial hemorrhage ( J:195902 )
• in some mice at E10.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory