Analysis Tools
mortality/aging
 |
• fewer than expected mice are recovered between E10.5 and E14.5
|
cardiovascular system
|
|
• reduce mural cell coverage in the dorsal aorta subdermal vessels at E10.5
• mice exhibit impaired differentiation of mural cells from mesoderm
• however, mural cell apoptosis, proliferation and coverage in the retina derived from migration is normal
|
|
|
• mice lack defined coronary arterioles
|
|
|
• at E14.5, vascular smooth muscle cells abnormally reside in the epicardial layer and reduced presence in the underlying myocardium compared to in wild-type mice
|
|
|
• sparse and disrupted
|
|
|
• in the coelomic cavity in some mice at E10.5
• severity varies based on reduced mural coverage
• however, some mice recover by E14.5
|
|
|
• in some mice at E10.5
|
|
|
• in some mice at E10.5
|
|
|
• in some mice at E10.5
|
muscle
|
|
• at E14.5, vascular smooth muscle cells abnormally reside in the epicardial layer and reduced presence in the underlying myocardium compared to in wild-type mice
|
|
|
• sparse and disrupted
|
nervous system
|
|
• in some mice at E10.5
|
homeostasis/metabolism
|
|
• in some mice at E10.5
|
vision/eye
|
N |
• P6 retina exhibit normal mural cell coverage
|
