Phenotypes associated with this allele

• Allele Symbol: Ube2q1^tm1Grz
• Allele Name: targeted mutation 1, Pawel Grzmil
• Allele ID: MGI:5486217
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ube2q1^tm1Grz/Ube2q1^tm1Grz	involves: 129S1/Sv * 129X1/SvJ	MGI:5486218

Genotype
MGI:5486218

hm1

• Allelic Composition: Ube2q1^tm1Grz/Ube2q1^tm1Grz
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality at implantation, incomplete penetrance ( J:195898 )

reproductive system

delayed female fertility ( J:195898 )

♀ • female mice produce their first litter in the 10th and 12th week compared with 8th and 9th week for wild-type mice

♀ • however, female mice ovulate

prolonged diestrus ( J:195898 )

♀

decreased litter size ( J:195898 )

• produced by female mice mated to wild-type or homozygous males

• slight decreased from males mated to wild-type mice

behavior/neurological

abnormal nursing ( J:195898 )

♀ • absence of gastric milk in pups that die after birth indicates an inability to properly feed pups

abnormal mating frequency ( J:195898 )

♀ • irregular in female mice

homeostasis/metabolism

decreased circulating prolactin level ( J:195898 )

♀ • in female mice

cellular

maternal effect ( J:195898 )

♀ • at E17.5, fewer pups are produced by homozygous female mice

♀ • most pups of homozygous female mice die within the first 48 h after birth with dehydration and no milk in the stomach of pups