Phenotypes associated with this allele

• Allele Symbol: Plekhg5^tm1Jbar
• Allele Name: targeted mutation 1, Jay Baraban
• Allele ID: MGI:5484788
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Plekhg5^tm1Jbar/Plekhg5^tm1Jbar Tg(Tek-cre)1Ywa/0	involves: C57BL/6 * SJL	MGI:5484864

Genotype
MGI:5484864

cn1

• Allelic Composition: Plekhg5^tm1Jbar/Plekhg5^tm1Jbar; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:195233 )

• sparser than in wild-type mice

abnormal vascular endothelial cell morphology ( J:195233 )

• mice exhibit defective endothelial cell junctions compared with wild-type mice

abnormal heart left ventricle morphology ( J:195233 )

• mice exhibit defective endothelial cell junctions compared with wild-type mice

decreased heart ventricle muscle contractility ( J:195233 )

• after partial aortic occlusion, mice exhibit decreased ejection fraction and twice as high ventricle passive stiffness compared with wild-type mice

increased vascular permeability ( J:195233 )

• leaky blood vessels with higher extravasation of fluorescent beads

homeostasis/metabolism

edema ( J:195233 )

impaired skin barrier function ( J:195233 )

• in untreated mice (3-fold) or mice treated with Ang1 (9-fold)

• however, treatment with VEGF does not exacerbate impaired skin barrier function

integument

impaired skin barrier function ( J:195233 )

• in untreated mice (3-fold) or mice treated with Ang1 (9-fold)

• however, treatment with VEGF does not exacerbate impaired skin barrier function

muscle

decreased heart ventricle muscle contractility ( J:195233 )

• after partial aortic occlusion, mice exhibit decreased ejection fraction and twice as high ventricle passive stiffness compared with wild-type mice