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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grb2tm3.1Paw
targeted mutation 3.1, Tony Pawson
MGI:5484776
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Grb2tm3.1Paw/Grb2tm3.1Paw
Tg(Nphs2-cre)1Seq/0 		involves: 129S1/Sv * 129X1/SvJ MGI:5484785
cn2
 		Grb2tm1Paw/Grb2tm3.1Paw
Tg(Nphs2-cre)1Seq/0 		involves: 129S1/Sv * 129X1/SvJ MGI:5484786
cn3
 		Grb2tm3.1Paw/Grb2tm3.1Paw
Tg(Nphs1-cre)2Seq/0 		involves: 129S1/Sv * 129X1/SvJ MGI:5484787


Genotype
MGI:5484785
cn1
Allelic
Composition		 Grb2tm3.1Paw/Grb2tm3.1Paw
Tg(Nphs2-cre)1Seq/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm3.1Paw mutation (1 available); any Grb2 mutation (45 available)
Tg(Nphs2-cre)1Seq mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:195444 )
N
• mice exhibit normal podocyte development and kidney function




Genotype
MGI:5484786
cn2
Allelic
Composition		 Grb2tm1Paw/Grb2tm3.1Paw
Tg(Nphs2-cre)1Seq/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm1Paw mutation (0 available); any Grb2 mutation (45 available)
Grb2tm3.1Paw mutation (1 available); any Grb2 mutation (45 available)
Tg(Nphs2-cre)1Seq mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:195444 )
N
• mice exhibit normal podocyte development and kidney function




Genotype
MGI:5484787
cn3
Allelic
Composition		 Grb2tm3.1Paw/Grb2tm3.1Paw
Tg(Nphs1-cre)2Seq/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm3.1Paw mutation (1 available); any Grb2 mutation (45 available)
Tg(Nphs1-cre)2Seq mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:195444 )
N
• mice exhibit normal kidney morphology and function
• adriamycin-injected mice exhibit normal recovery following injury




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory