Phenotypes associated with this allele

• Allele Symbol: Ints15⁺
• Allele Name: wild type
• Allele ID: MGI:5482819
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ints15^em1Takas/Ints15^+	involves: C57BL/6 * DBA/2	MGI:7628244
ht2	Ints15^em2Takas/Ints15^+	involves: C57BL/6 * DBA/2	MGI:7628246

Genotype
MGI:7628244

ht1

• Allelic Composition: Ints15^em1Takas/Ints15⁺
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye morphology ( J:337973 )

• 3% of mice show local chorioretinal atrophy

• however, no retinal folds, cataracts, corneal opacity, iris anomaly, Peters anomaly or microphthalmos are observed

abnormal retina blood vessel morphology ( J:337973 )

• 26% of mice exhibit narrowing of retinal vessels

• 7% of mice show sheathing of retinal vessels

• however, no retinal hemangioma is observed

abnormal optic disk morphology ( J:337973 )

• 14% of mice show a pigmentation phenotype in the optic nerve head

• however, no optic nerve head anomaly is observed

abnormal eye development ( J:337973 )

persistence of hyaloid vascular system ( J:337973 )

• 55% of mice show persistence of ocular fetal vasculature (PFV) on the optic nerve head

cardiovascular system

abnormal retina blood vessel morphology ( J:337973 )

• 26% of mice exhibit narrowing of retinal vessels

• 7% of mice show sheathing of retinal vessels

• however, no retinal hemangioma is observed

nervous system

abnormal optic disk morphology ( J:337973 )

• 14% of mice show a pigmentation phenotype in the optic nerve head

• however, no optic nerve head anomaly is observed

Genotype
MGI:7628246

ht2

• Allelic Composition: Ints15^em2Takas/Ints15⁺
• Genetic Background: involves: C57BL/6 * DBA/2

vision/eye

abnormal eye morphology ( J:337973 )

• 43% of mice show local chorioretinal atrophy

abnormal retina blood vessel morphology ( J:337973 )

• 43% of mice exhibit narrowing of retinal vessels

• 56% of mice show sheathing of retinal vessels

increased retina hemangioma incidence ( J:337973 )

• 6% of mice exhibit hemangioma in retinal vessels

abnormal optic disk morphology ( J:337973 )

• 17% of mice exhibit an optic nerve head anomaly

• 23% of mice show a pigmentation phenotype in the optic nerve head

abnormal anterior eye segment morphology ( J:337973 )

• 9% of mice exhibit Peters anomaly (anterior segment dysgenesis)

abnormal iris morphology ( J:337973 )

• 11% of mice exhibit iris anomaly

anterior iris synechia ( J:337973 )

• adhesion of the cornea to the iris is observed

cornea opacity ( J:337973 )

• 17% of mice exhibit corneal opacity

lens dislocation ( J:337973 )

• ectopic lens tissue is observed

cataract ( J:337973 )

• 24% of mice exhibit cataracts

abnormal eye development ( J:337973 )

• mice exhibit more severe malformations in various eye tissues than Ints15^em1Takas homozygotes

persistence of hyaloid vascular system ( J:337973 )

• 69% of mice exhibit prominent persistence of ocular fetal vasculature (PFV) radiating from the optic nerve head to the lens

microphthalmia ( J:337973 )

• 17% of mice exhibit microphthalmos with malformation of whole ocular tissues

retina fold ( J:337973 )

• 11% of mice exhibit retinal folds

cardiovascular system

abnormal retina blood vessel morphology ( J:337973 )

• 43% of mice exhibit narrowing of retinal vessels

• 56% of mice show sheathing of retinal vessels

nervous system

abnormal optic disk morphology ( J:337973 )

• 17% of mice exhibit an optic nerve head anomaly

• 23% of mice show a pigmentation phenotype in the optic nerve head

neoplasm

increased retina hemangioma incidence ( J:337973 )

• 6% of mice exhibit hemangioma in retinal vessels