About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bbln+
wild type
MGI:5481956
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Bblntm1(KOMP)Wtsi/Bbln+ involves: C57BL/6N MGI:6473316


Genotype
MGI:6473316
ht1
Allelic
Composition		 Bblntm1(KOMP)Wtsi/Bbln+
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bblntm1(KOMP)Wtsi mutation (1 available); any Bbln mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal osteoclast differentiation ( J:296689 )
• differentiation of BMMs (bone marrow-derived monocytes/macrophages) into large hyper-nucleated osteoclasts 3 days after RANKL stimulation in vitro
• differentiation of BMMs (bone marrow-derived monocytes/macrophages) into multinucleated osteoclasts 1 day earlier after RANKL stimulation in vitro than wild-type

skeleton
abnormal osteoclast differentiation ( J:296689 )
• differentiation of BMMs (bone marrow-derived monocytes/macrophages) into large hyper-nucleated osteoclasts 3 days after RANKL stimulation in vitro
• differentiation of BMMs (bone marrow-derived monocytes/macrophages) into multinucleated osteoclasts 1 day earlier after RANKL stimulation in vitro than wild-type

immune system
abnormal osteoclast differentiation ( J:296689 )
• differentiation of BMMs (bone marrow-derived monocytes/macrophages) into large hyper-nucleated osteoclasts 3 days after RANKL stimulation in vitro
• differentiation of BMMs (bone marrow-derived monocytes/macrophages) into multinucleated osteoclasts 1 day earlier after RANKL stimulation in vitro than wild-type

hematopoietic system
abnormal osteoclast differentiation ( J:296689 )
• differentiation of BMMs (bone marrow-derived monocytes/macrophages) into large hyper-nucleated osteoclasts 3 days after RANKL stimulation in vitro
• differentiation of BMMs (bone marrow-derived monocytes/macrophages) into multinucleated osteoclasts 1 day earlier after RANKL stimulation in vitro than wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory