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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trem2+
wild type
MGI:5481162
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Trem2em2Bwef/Trem2+ involves: C57BL/6J * DBA/2J * FVB/N MGI:5904596
cx2
 		Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Trem2em1Gela/Trem2+ 		involves: C57BL/6J MGI:6198554
cx3
 		Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Trem2tm1(KOMP)Vlcg/Trem2+ 		involves: C57BL/6J * C57BL/6NTac MGI:6198555


Genotype
MGI:5904596
ht1
Allelic
Composition		 Trem2em2Bwef/Trem2+
Genetic
Background		 involves: C57BL/6J * DBA/2J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trem2em2Bwef mutation (0 available); any Trem2 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased macrophage cell number ( J:242126 )
• fewer macrophages are produced from bone marrow cells stimulated with colony-stimulating factor

immune system
decreased macrophage cell number ( J:242126 )
• fewer macrophages are produced from bone marrow cells stimulated with colony-stimulating factor




Genotype
MGI:6198554
cx2
Allelic
Composition		 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Trem2em1Gela/Trem2+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
Trem2em1Gela mutation (0 available); any Trem2 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased myeloid cell number ( J:264653 )
• mice show a reduction in the number of plaque-associated myeloid cells compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating an impairment in myeloid cell accumulation around plaques
abnormal hematopoietic system physiology ( J:264653 )
• proliferation of myeloid cells is reduced compared to levels in single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

homeostasis/metabolism
amyloid beta deposits ( J:264653 )
• mice show a 31% and 36% reduction in compact fibrillary, thioflavin S positive plaque number and percent area, respectively, in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating altered plaque structure
• however, the total number of cortical plaques and percent area is similar to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
• mice show a decrease in soluble amyloid beta 1-40 in the cortex and thus an increased ratio of amyloid beta 42/40 compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

nervous system
amyloid beta deposits ( J:264653 )
• mice show a 31% and 36% reduction in compact fibrillary, thioflavin S positive plaque number and percent area, respectively, in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating altered plaque structure
• however, the total number of cortical plaques and percent area is similar to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
• mice show a decrease in soluble amyloid beta 1-40 in the cortex and thus an increased ratio of amyloid beta 42/40 compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
abnormal neurite morphology ( J:264653 )
• marker analysis indicates increased plaque-associated neuritic dystrophy compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice




Genotype
MGI:6198555
cx3
Allelic
Composition		 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Trem2tm1(KOMP)Vlcg/Trem2+
Genetic
Background		 involves: C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
Trem2tm1(KOMP)Vlcg mutation (1 available); any Trem2 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased myeloid cell number ( J:264653 )
• mice show a reduction in the number of plaque-associated myeloid cells compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating an impairment in myeloid cell accumulation around plaques
abnormal hematopoietic system physiology ( J:264653 )
• proliferation of myeloid cells is reduced compared to levels in single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

homeostasis/metabolism
amyloid beta deposits ( J:264653 )
• mice exhibit a modest increase in the total cortical plaque number and percent area compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
• mice show an increase in soluble amyloid beta 1-40 in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

nervous system
amyloid beta deposits ( J:264653 )
• mice exhibit a modest increase in the total cortical plaque number and percent area compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
• mice show an increase in soluble amyloid beta 1-40 in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
abnormal neurite morphology ( J:264653 )
• marker analysis indicates increased plaque-associated neuritic dystrophy compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory