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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col1a1tm1(tetO-Yod1*)Hpl
targeted mutation 1, Hidde Ploegh
MGI:5478606
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Col1a1tm1(tetO-Yod1*)Hpl/Col1a1tm1(tetO-Yod1*)Hpl
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Tap1tm1Arp/Tap1tm1Arp 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:5478623
cx2
 		Col1a1tm1(tetO-Yod1*)Hpl/Col1a1tm1(tetO-Yod1*)Hpl
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae 		involves: 129S4/SvJae * C57BL/6 MGI:5478622


Genotype
MGI:5478623
cx1
Allelic
Composition		 Col1a1tm1(tetO-Yod1*)Hpl/Col1a1tm1(tetO-Yod1*)Hpl
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Tap1tm1Arp/Tap1tm1Arp
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-Yod1*)Hpl mutation (0 available); any Col1a1 mutation (160 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (942 available)
Tap1tm1Arp mutation (4 available); any Tap1 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal professional antigen presenting cell physiology ( J:194608 )
• APCs from doxycycline-treated mice exhibit enhanced antigen cross-presentation compared with control cells




Genotype
MGI:5478622
cx2
Allelic
Composition		 Col1a1tm1(tetO-Yod1*)Hpl/Col1a1tm1(tetO-Yod1*)Hpl
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-Yod1*)Hpl mutation (0 available); any Col1a1 mutation (160 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:194608 )
N
• doxycycline-treated mice exhibit normal T cell distribution in lymphoid organs
abnormal CD8-positive, alpha-beta T cell physiology ( J:194608 )
• CD8+ T cells from doxycycline-treated mice exhibit enhanced response to immunization with viral infection and improved viral growth control compared with control cells
abnormal professional antigen presenting cell physiology ( J:194608 )
• following exposure to ovalbumin, antigen presenting cells (APCs) from doxycycline-treated mice exhibit enhanced antigen cross-production with increased induction of proliferation and IL2 production in OT-I cells compared with control cells
• following infection with MHV-68 and irradiation, bone marrow derived dendritic cells from doxycycline-treated mice prime more effective CD8+ T cell response compared with control cells
• APCs from doxycycline-treated mice exhibit prolonged antigen retention compared with control cells
• cross-presentation in doxycycline-treated mice requires acidification and is insensitive to brefeldin compared to in control cells
• however, antigen presentation in doxycycline-treated mice is normal

hematopoietic system
abnormal CD8-positive, alpha-beta T cell physiology ( J:194608 )
• CD8+ T cells from doxycycline-treated mice exhibit enhanced response to immunization with viral infection and improved viral growth control compared with control cells




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory