Phenotypes associated with this allele

• Allele Symbol: Siglec15^tm1Yohi
• Allele Name: targeted mutation 1, Yoshiharu Hiruma
• Allele ID: MGI:5478584
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Siglec15^tm1Yohi/Siglec15^tm1Yohi	B6.129S6-Siglec15^tm1Yohi	MGI:5478589

Genotype
MGI:5478589

hm1

• Allelic Composition: Siglec15^tm1Yohi/Siglec15^tm1Yohi
• Genetic Background: B6.129S6-Siglec15^tm1Yohi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:193852 )

N • mice exhibit normal skeletal growth

abnormal osteoclast differentiation ( J:193852 )

• impaired differentiation from bone marrow-derived monocytes/macrophage

abnormal osteoblast physiology ( J:193852 )

• reduced bone formation rate per unit bone surface

increased bone mineral content ( J:193852 )

• increase in trabecular volumetric bone mineral content in the distal femoral metaphysis

• slightly in the cortical bone of the femoral diaphysis of female, but not male, mice

increased bone mineral density ( J:193852 )

• increased bone mineral density in the distal femur and proximal tibia

increased areal bone mineral density ( J:193852 )

• increase in areal bone mineral density, especially from the distal metaphysis to the midshaft of the femur

increased bone mineral density of femur ( J:193852 )

• increase in bone mineral density in the distal femur

• increase in areal bone mineral density, especially from the distal metaphysis to the midshaft of the femur

increased trabecular bone volume ( J:193852 )

• especially in the secondary spongiosa and epiphyseal ossification center

increased compact bone area ( J:193852 )

♀ • slightly in female, but not male, mice

decreased osteoblast cell number ( J:193852 )

increased bone trabecula number ( J:193852 )

• especially in the secondary spongiosa and epiphyseal ossification center

increased trabecular bone mass ( J:193852 )

• in the fifth lumbar vertebrae

osteopetrosis ( J:193852 )

• mild at 18 weeks of age, especially in the distal femur and proximal tibia

• however, bone length and tooth eruption are normal

abnormal bone ossification ( J:193852 )

• reduced bone formation rate per unit bone surface

• enhanced bone formation in female mice

decreased bone resorption ( J:193852 )

♀ • in female, but not male, mice

homeostasis/metabolism

increased circulating osteocalcin level ( J:193852 )

♀ • increased serum osteocalcin levels in female, but not male, mice at 18 weeks

abnormal urine homeostasis ( J:193852 )

• at 9 and 18 weeks, mice exhibit decreased urinary secretion of deoxypyridinoline compared with wild-type mice

renal/urinary system

abnormal urine homeostasis ( J:193852 )

• at 9 and 18 weeks, mice exhibit decreased urinary secretion of deoxypyridinoline compared with wild-type mice

cellular

abnormal osteoclast differentiation ( J:193852 )

• impaired differentiation from bone marrow-derived monocytes/macrophage

abnormal osteoblast physiology ( J:193852 )

• reduced bone formation rate per unit bone surface

hematopoietic system

abnormal osteoclast differentiation ( J:193852 )

• impaired differentiation from bone marrow-derived monocytes/macrophage

immune system

abnormal osteoclast differentiation ( J:193852 )

• impaired differentiation from bone marrow-derived monocytes/macrophage