Phenotypes associated with this allele

• Allele Symbol: Gip^tm1Nina
• Allele Name: targeted mutation 1, Nobuya Inagaki
• Allele ID: MGI:5478539
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gip^tm1Nina/Gip^tm1Nina	involves: C57BL/6	MGI:7766958
ht2	Gip^tm1Nina/Gip^+	involves: C57BL/6	MGI:5478542

Genotype
MGI:7766958

hm1

• Allelic Composition: Gip^tm1Nina/Gip^tm1Nina
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating insulin level ( J:298236 )

• at 25 weeks of age

increased energy expenditure ( J:298236 )

• at 51 weeks of age

• however, no difference in locomotor activity or food intake

liver/biliary system

abnormal liver morphology ( J:298236 )

• reduced fat content in the liver at 58 weeks of age

adipose tissue

abnormal adipose tissue amount ( J:298236 )

• decreased visceral fat weight at 60 weeks of age

decreased subcutaneous adipose tissue amount ( J:298236 )

• at 60 weeks of age

decreased total body fat amount ( J:298236 )

• at 60 weeks of age

growth/size/body

decreased body weight ( J:298236 )

• at 38 weeks of age

• however, lean body mass is not different from wild-type or heterozygous controls

integument

decreased subcutaneous adipose tissue amount ( J:298236 )

• at 60 weeks of age

Genotype
MGI:5478542

ht2

• Allelic Composition: Gip^tm1Nina/Gip⁺
• Genetic Background: involves: C57BL/6

digestive/alimentary system

digestive/alimentary phenotype ( J:193877 )

N • mice fed a high fat diet have normal K-cell number

growth/size/body

growth/size/body region phenotype ( J:193877 )

N • mice fed a high fat diet exhibit obesity and insulin hypersecretion

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:193877 )

N • mice fed a high fat diet exhibit obesity and insulin hypersecretion