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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Myh6-icre/ERT2)#Wet
transgene insertion, Nina Wettschureck
MGI:5477906
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gja1tm10Kwi/Gja1tm10Kwi
Tg(Myh6-icre/ERT2)#Wet/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:5477914
cn2
 		Gjc1tm1Kwi/Gjc1tm1Kwi
Tg(Myh6-icre/ERT2)#Wet/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:5544304
cn3
 		Gjc1tm1Kwi/Gjc1tm1Kwi
Gjd3tm2.1Kwi/Gjd3tm2.1Kwi
Tg(Myh6-icre/ERT2)#Wet/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL MGI:5544303


Genotype
MGI:5477914
cn1
Allelic
Composition		 Gja1tm10Kwi/Gja1tm10Kwi
Tg(Myh6-icre/ERT2)#Wet/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1tm10Kwi mutation (1 available); any Gja1 mutation (59 available)
Tg(Myh6-icre/ERT2)#Wet mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:194957 )
• all mice die 16 to 21 days after tamoxifen-treatment

cardiovascular system
cardiovascular system phenotype ( J:194957 )
N
• mice exhibit normal heart beating frequency and PQ duration
ventricular tachycardia ( J:194957 )
• sustained polymorphic ventricular tachycardia degenerating into ventricular fibrillation in tamoxifen-treated mice
• tamoxifen-treated mice exhibit sustained ventricular tachycardia or ventricular fibrillation induced by fixed-rate epicardial stimulation of the ventricle unlike control mice
irregular heartbeat ( J:194957 )
• non-sustained episodes of monomorphic and polymorphic ventricular arrhythmias 15 to 17 days after tamoxifen-treatment
ventricular fibrillation ( J:194957 )
• in tamoxifen-treated mice
atrioventricular block ( J:194957 )
• in tamoxifen-treated mice
prolonged QRS complex duration ( J:194957 )
• 2.1-fold in tamoxifen-treated mice
abnormal myocardial fiber physiology ( J:194957 )
• cardiomyocytes form tamoxifen-treated mice exhibit reduced average peak inward sodium current density, prolonged time course of inward sodium channel inactivation, reduced average peak outward current density and increased action potential duration at 50 and 70% depolarization compared with control cells
• however, cardiomyocytes exhibit normal voltage-dependent inactivation, time course of recovery from inactivation, density of inward rectifier current, resting potential, action potential amplitude and action potential duration at 90% repolarization




Genotype
MGI:5544304
cn2
Allelic
Composition		 Gjc1tm1Kwi/Gjc1tm1Kwi
Tg(Myh6-icre/ERT2)#Wet/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1tm1Kwi mutation (1 available); any Gjc1 mutation (33 available)
Tg(Myh6-icre/ERT2)#Wet mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:205110 )
• embryos treated with tamoxifen at E8.5 and E9.5 die beyond E10.5
• however, mice not treated with tamoxifen develop normally

cardiovascular system
cardiovascular system phenotype ( J:205110 )
N
• tamoxifen-treated mice do not exhibit spontaneous AV block, supraventricular or ventricular ectopic beats or arrhythmia
abnormal heart electrocardiography waveform feature ( J:205110 )
• tamoxifen-treated mice exhibit prolonged atria-His (AH) interval compared with control mice
prolonged PQ interval ( J:205110 )
• in tamoxifen-treated mice
abnormal sinoatrial node conduction ( J:205110 )
• tamoxifen-treated mice exhibit shorter sinus node recovery rate compared with control mice




Genotype
MGI:5544303
cn3
Allelic
Composition		 Gjc1tm1Kwi/Gjc1tm1Kwi
Gjd3tm2.1Kwi/Gjd3tm2.1Kwi
Tg(Myh6-icre/ERT2)#Wet/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1tm1Kwi mutation (1 available); any Gjc1 mutation (33 available)
Gjd3tm2.1Kwi mutation (1 available); any Gjd3 mutation (13 available)
Tg(Myh6-icre/ERT2)#Wet mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:205110 )
N
• tamoxifen-treated mice are viable

cardiovascular system
cardiovascular system phenotype ( J:205110 )
N
• tamoxifen-treated mice exhibit normal heart morphology, equal heart rates, P-wave duration, QRS intervals and QTc intervals without spontaneous AV block, supraventricular or ventricular ectopic beats or arrhythmia
abnormal heart electrocardiography waveform feature ( J:205110 )
• tamoxifen-treated mice exhibit prolonged atria-His (AH) interval and Wenckebach periodicity compared with control mice
prolonged PQ interval ( J:205110 )
• in tamoxifen-treated mice
abnormal sinoatrial node conduction ( J:205110 )
• tamoxifen-treated mice exhibit shorter sinus node recovery rate compared with control mice




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory