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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rgs4tm1.1Amus
targeted mutation 1.1, Anthony J Muslin
MGI:5476691
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rgs4tm1.1Amus/Rgs4tm1.1Amus B6.129-Rgs4tm1.1Amus MGI:5476694


Genotype
MGI:5476694
hm1
Allelic
Composition		 Rgs4tm1.1Amus/Rgs4tm1.1Amus
Genetic
Background		 B6.129-Rgs4tm1.1Amus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs4tm1.1Amus mutation (0 available); any Rgs4 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:195186 )
• means survival of mice treated with cyclosporine A is 9 days compared with 25 days for wild-type mice

renal/urinary system
decreased renal plasma flow rate ( J:195186 )
• in mice treated with cyclosporine A, specifically in the medulla and cortex
• however, treatment with bosentan restores renal plasma flow rate

cardiovascular system
decreased renal plasma flow rate ( J:195186 )
• in mice treated with cyclosporine A, specifically in the medulla and cortex
• however, treatment with bosentan restores renal plasma flow rate

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:195186 )
• means survival of mice treated with cyclosporine A is 9 days compared with 25 days for wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory