Phenotypes associated with this allele

• Allele Symbol: Etv2^tm1Vkou
• Allele Name: targeted mutation 1, Valerie Kouskoff
• Allele ID: MGI:5474866
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Etv2^tm1Vkou/Etv2^tm1Vkou Tg(Pgk1-cre)1Lni/0	involves: BALB/c * C57BL/6	MGI:5474869
cn2	Etv2^tm1Vkou/Etv2^tm1Vkou Tg(Tek-cre)1Ywa/0	involves: C57BL/6 * SJL	MGI:5474868

Genotype
MGI:5474869

cn1

• Allelic Composition: Etv2^tm1Vkou/Etv2^tm1Vkou; Tg(Pgk1-cre)1Lni/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:194572 )

• mice die by E9.5

hematopoietic system

absent erythroid progenitor cell ( J:194572 )

• both primitive erythroid and all definitive progenitors

• however, expression of Tal1/Scl rescues hematopoietic defects in embryoid bodies

absent erythrocytes ( J:194572 )

• lack of visible red blood cells

embryo

embryonic growth retardation ( J:194572 )

• severe

growth/size/body

embryonic growth retardation ( J:194572 )

• severe

Genotype
MGI:5474868

cn2

• Allelic Composition: Etv2^tm1Vkou/Etv2^tm1Vkou; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * SJL

normal phenotype

no abnormal phenotype detected ( J:194572 )

• mice are viable, grossly normal and fertile