Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm1.1Brei mutation
(0 available);
any
Egln1 mutation
(21 available)
Hif1atm3Rsjo mutation
(3 available);
any
Hif1a mutation
(48 available)
Tg(CD68-icre)1Bwlx mutation
(0 available)
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mortality/aging
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• mice start dying suddenly at 5 weeks with 95% mortality by 16 weeks (mean survival time = 11 weeks)
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hematopoietic system
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N |
• no cardiovascular complications or thromboses are observed
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• not different from CD68cre/Phd2fl mice
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craniofacial
nervous system
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• mice with domed skulls show dramatic hydrocephalus
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skeleton
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1atm3Rsjo mutation
(3 available);
any
Hif1a mutation
(48 available)
Tg(CD68-icre)1Bwlx mutation
(0 available)
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mortality/aging
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N |
• no premature death observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm1.1Brei mutation
(0 available);
any
Egln1 mutation
(21 available)
Egln3tm2Fong mutation
(1 available);
any
Egln3 mutation
(24 available)
Tg(CD68-icre)1Bwlx mutation
(0 available)
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hematopoietic system
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• mice display severe erythrocytosis
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mortality/aging
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• animals start dying shortly after birth
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm1.1Brei mutation
(0 available);
any
Egln1 mutation
(21 available)
Epas1tm1Mcs mutation
(1 available);
any
Epas1 mutation
(64 available)
Tg(CD68-icre)1Bwlx mutation
(0 available)
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mortality/aging
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N |
• no premature death is observed
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hematopoietic system
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N |
• erythropoiesis phenotype seen in Phd2 single mutants is absent from double mutants
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• HCT is lower than wild type
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• lower than in wild-type
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epas1tm1Mcs mutation
(1 available);
any
Epas1 mutation
(64 available)
Tg(CD68-icre)1Bwlx mutation
(0 available)
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|
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mortality/aging
|
N |
• no premature death observed
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|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm1.1Brei mutation
(0 available);
any
Egln1 mutation
(21 available)
Tg(CD68-icre)1Bwlx mutation
(0 available)
|
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mortality/aging
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N |
• no premature death is observed; some erythrocytotic mutants live for more than 20 months with no observed decrease in hematocrit
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growth/size/body
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• severe growth retardation occurs in conjunction with skin redness until adulthood
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hematopoietic system
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N |
• F4/80+ macrophages and neutrophils are not significantly different from wild type, but red pulp macrophages are highly induced in the spleen
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• megakaryocyte-erythroid progenitors (MEPs) are significantly induced (>2.5 fold) in the spleen, but not in bone marrow
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• splenic CD71+ve/Ter119+ve erythroblasts are increase >10-fold with mild increase in bone marrow
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• results in splenomegaly
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• increases with age to >85% in some animals
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• splenomegaly occurs with increase in nucleated cells
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• significantly decreased
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• fraction of B and T cells in spleen is significantly decreased but in lymph nodes these numbers are increased
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• splenomegaly occurs with loss of splenic architecture
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cardiovascular system
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• viscosity is increased but no differences in heart rate, blood pressure or cardiac hypertrophy is observed
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• blood volume increased by 65%
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immune system
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• fraction of B and T cells in spleen is significantly decreased but in lymph nodes these numbers are increased
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• splenomegaly occurs with loss of splenic architecture
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integument
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• redness of paws and snouts is observed by 4 weeks of age
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Analysis Tools