Phenotypes associated with this allele

• Allele Symbol: Trib3^tm1Tord
• Allele Name: targeted mutation 1, Tonis Ord
• Allele ID: MGI:5474051
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trib3^tm1Tord/Trib3^tm1Tord	involves: C57BL/6	MGI:5474052

Genotype
MGI:5474052

hm1

• Allelic Composition: Trib3^tm1Tord/Trib3^tm1Tord
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal mast cell physiology ( J:192615 )

• cultured bone marrow derived mast cells display increased sensitivity to cell cycle arrest and cell death in response to Il3 deprivation

decreased mast cell degranulation ( J:192615 )

• reduced in cultured bone marrow derived mast cells in response to sensitizing with anti-DNP IgE followed by stimulation with DNP-BSA or treatment with ionomycin in conjunction with PMA

hematopoietic system

abnormal mast cell physiology ( J:192615 )

• cultured bone marrow derived mast cells display increased sensitivity to cell cycle arrest and cell death in response to Il3 deprivation

decreased mast cell degranulation ( J:192615 )

• reduced in cultured bone marrow derived mast cells in response to sensitizing with anti-DNP IgE followed by stimulation with DNP-BSA or treatment with ionomycin in conjunction with PMA

cellular

decreased mast cell degranulation ( J:192615 )

• reduced in cultured bone marrow derived mast cells in response to sensitizing with anti-DNP IgE followed by stimulation with DNP-BSA or treatment with ionomycin in conjunction with PMA