About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mcm4Sdla
Spontaneous dominant leukemia
MGI:5473704
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mcm4Sdla/Mcm4Sdla involves: C57BL/6 MGI:5473715
ht2
 		Mcm4Sdla/Mcm4+ involves: C57BL/6 MGI:5473713
ht3
 		Mcm4chaos3/Mcm4Sdla involves: C57BL/6 * C57BL/6J MGI:5473714


Genotype
MGI:5473715
hm1
Allelic
Composition		 Mcm4Sdla/Mcm4Sdla
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm4Sdla mutation (0 available); any Mcm4 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:194117 )
• no mice are present as early as E8.5




Genotype
MGI:5473713
ht2
Allelic
Composition		 Mcm4Sdla/Mcm4+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm4Sdla mutation (0 available); any Mcm4 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:194117 )
• in moribund mice
enlarged lymph nodes ( J:194117 )
• in moribund mice

neoplasm
increased tumor incidence ( J:194117 )
• hematologic malignancy including mediastinal masses, splenomegaly and/or lymphadenopathy in 180 of 191 moribund mice
increased acute lymphoblastic leukemia incidence ( J:194117 )
• early onset T cell acute lymphoblastic leukemia (T-ALL)

cellular
induced chromosome breakage ( J:194117 )
• in mouse embryonic fibroblasts in the presence or absence of aphidicolin
spontaneous chromosome breakage ( J:194117 )
• in mouse embryonic fibroblasts in the presence or absence of aphidicolin

hematopoietic system
enlarged spleen ( J:194117 )
• in moribund mice
reticulocytosis ( J:194117 )
• 18-fold increase in micronucleated reticulocytes

endocrine/exocrine glands

growth/size/body
enlarged spleen ( J:194117 )
• in moribund mice




Genotype
MGI:5473714
ht3
Allelic
Composition		 Mcm4chaos3/Mcm4Sdla
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm4chaos3 mutation (1 available); any Mcm4 mutation (43 available)
Mcm4Sdla mutation (0 available); any Mcm4 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:194117 )
• no mice are present at P1




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory