All Phenotypes Ptgdr<tm1Dgen> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ptgdr^tm1Dgen
targeted mutation 1, Deltagen
MGI:5473328

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptgdr^tm1Dgen/Ptgdr^tm1Dgen	B6.129P2-Ptgdr^tm1Dgen	MGI:5473341
ht2	Ptgdr^tm1Dgen/Ptgdr⁺	B6.129P2-Ptgdr^tm1Dgen	MGI:5473342
cx3	Apoe^tm1Unc/Apoe^tm1Unc Ptgdr^tm1Dgen/Ptgdr^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:5473362

Allelic Composition	Ptgdr^tm1Dgen/Ptgdr^tm1Dgen
Genetic Background	B6.129P2-Ptgdr^tm1Dgen

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgdr^tm1Dgen mutation (0 available); any Ptgdr mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased vasodilation ( J:109107 )

• mice fail to exhibit a vasodilation response to low levels of nicotinic acid compared with wild-type mice

• male mice treated with nicotinic acid and aspirin fail to exhibit a vasodilation response compared with control mice

• however, response to high levels is normal

muscle

decreased vasodilation ( J:109107 )

• mice fail to exhibit a vasodilation response to low levels of nicotinic acid compared with wild-type mice

• male mice treated with nicotinic acid and aspirin fail to exhibit a vasodilation response compared with control mice

• however, response to high levels is normal

Allelic Composition	Ptgdr^tm1Dgen/Ptgdr⁺
Genetic Background	B6.129P2-Ptgdr^tm1Dgen

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgdr^tm1Dgen mutation (0 available); any Ptgdr mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased vasodilation ( J:109107 )

• male and female mice exhibit reduced vasodilation response to low levels of nicotinic acid compared with wild-type mice

increased vasodilation ( J:109107 )

• male mice treated with high levels of nicotinic acid exhibit a more robust average vasodilation compared with wild-type mice

• however, female mice exhibit normal response to high levels of nicotinic acid

muscle

decreased vasodilation ( J:109107 )

• male and female mice exhibit reduced vasodilation response to low levels of nicotinic acid compared with wild-type mice

increased vasodilation ( J:109107 )

• male mice treated with high levels of nicotinic acid exhibit a more robust average vasodilation compared with wild-type mice

• however, female mice exhibit normal response to high levels of nicotinic acid

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Ptgdr^tm1Dgen/Ptgdr^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (145 available)
Ptgdr^tm1Dgen mutation (0 available); any Ptgdr mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating triglyceride level ( J:192168 )

• in 1 of 2 studies of mice fed a high fat diet

increased cholesterol level ( J:192168 )

• modest in the aorta at 16 and 24, but not 32, weeks in mice fed a high fat diet

increased circulating cholesterol level ( J:192168 )

• in some mice fed a high fat diet

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