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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prl2c2tm1(cre)Gle
targeted mutation 1, Gustavo Leone
MGI:5472136
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Prl2c2tm1(cre)Gle/Prl2c2+ 		involves: 129S6/SvEvTac MGI:5473261
cn2
 		Orc1tm1.1Gle/Orc1tm1.1Gle
Prl2c2tm1(cre)Gle/Prl2c2+ 		involves: C57BL/6 * SJL MGI:6388638
cn3
 		Orc1tm1.1Gle/Orc1tm1.2Gle
Prl2c2tm1(cre)Gle/Prl2c2+ 		involves: C57BL/6 * SJL MGI:7408236


Genotype
MGI:5473261
cn1
Allelic
Composition		 E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Prl2c2tm1(cre)Gle/Prl2c2+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation (0 available); any E2f7 mutation (32 available)
E2f8tm1Gle mutation (0 available); any E2f8 mutation (34 available)
Prl2c2tm1(cre)Gle mutation (0 available); any Prl2c2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:6388638
cn2
Allelic
Composition		 Orc1tm1.1Gle/Orc1tm1.1Gle
Prl2c2tm1(cre)Gle/Prl2c2+
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Orc1tm1.1Gle mutation (0 available); any Orc1 mutation (60 available)
Prl2c2tm1(cre)Gle mutation (0 available); any Prl2c2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:272584 )
• E10.5 embryos are viable and live mice are recovered at 3 weeks of age; placentae appear histologically normal and show no major alterations in trophoblast giant cell (TGC) endoreduplication, as determined by the nuclear size, genomic DNA content, BrdU incorporation and Ccna2 expression in E10.5 TGCs




Genotype
MGI:7408236
cn3
Allelic
Composition		 Orc1tm1.1Gle/Orc1tm1.2Gle
Prl2c2tm1(cre)Gle/Prl2c2+
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Orc1tm1.1Gle mutation (0 available); any Orc1 mutation (60 available)
Orc1tm1.2Gle mutation (0 available); any Orc1 mutation (60 available)
Prl2c2tm1(cre)Gle mutation (0 available); any Prl2c2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:272584 )
• placental development is normal, embryos are carried to term and all pups born exhibit no apparent abnormalities




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory