Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(RICTOR)Jger}
• Allele Name: targeted mutation 1, Joseph Gera
• Allele ID: MGI:5471977
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(RICTOR)Jger/Gt(ROSA)26Sor^tm1(RICTOR)Jger Tg(GFAP-cre)25Mes/0	involves: 129 * FVB/N	MGI:5472015
cn2	Gt(ROSA)26Sor^tm1(RICTOR)Jger/Gt(ROSA)26Sor^tm1(RICTOR)Jger Tg(GFAP-cre)25Mes/0 Tg(GFAP-EGFR*,-lacZ)#Agu/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5472016

Genotype
MGI:5472015

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger}; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gliomas in Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger} Tg(GFAP-cre)25Mes/0 mice

mortality/aging

premature death ( J:192206 )

• most mice succumb to gliomas by 22 weeks

neoplasm

abnormal tumor vascularization ( J:192206 )

• intratumoral hemorrhage

increased glioma incidence ( J:192206 )

• bilateral, multifocal infiltrating glioma in the amygdalohippocampal region or surrounding cortex in close proximity to the subventricular zone

increased oligodendroglioma incidence ( J:192206 )

• infiltrating gliomas exhibit oligodendroglial-like features with the typical fried egg appearance

nervous system

increased glioma incidence ( J:192206 )

• bilateral, multifocal infiltrating glioma in the amygdalohippocampal region or surrounding cortex in close proximity to the subventricular zone

increased oligodendroglioma incidence ( J:192206 )

• infiltrating gliomas exhibit oligodendroglial-like features with the typical fried egg appearance

abnormal postnatal subventricular zone morphology ( J:192206 )

• 2-fold increase in thickness

cardiovascular system

abnormal tumor vascularization ( J:192206 )

• intratumoral hemorrhage

Genotype
MGI:5472016

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger}; Tg(GFAP-cre)25Mes/0; Tg(GFAP-EGFR*,-lacZ)#Agu/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Increased grade of oligodendroglioma in Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger} Tg(GFAP-EGFR*,-lacZ)#Agu/0 Tg(GFAP-cre)25Mes/0 mice

mortality/aging

premature death ( J:192206 )

• all mice succumb to gliomas by 18 weeks

neoplasm

increased glioma incidence ( J:192206 )

• mice exhibit accelerated glioma development compared with Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger} Tg(GFAP-cre)25Mes mice

increased astrocytoma incidence ( J:192206 )

• mixed astrocytic-oligodendroglial tumors

increased oligodendroglioma incidence ( J:192206 )

• mixed astrocytic-oligodendroglial tumors

decreased tumor latency ( J:192206 )

• mice exhibit accelerated glioma development compared with Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger} Tg(GFAP-cre)25Mes mice

nervous system

increased glioma incidence ( J:192206 )

• mice exhibit accelerated glioma development compared with Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger} Tg(GFAP-cre)25Mes mice

increased astrocytoma incidence ( J:192206 )

• mixed astrocytic-oligodendroglial tumors

increased oligodendroglioma incidence ( J:192206 )

• mixed astrocytic-oligodendroglial tumors

abnormal postnatal subventricular zone morphology ( J:192206 )

• 3-fold increase in thickness