Phenotypes associated with this allele

• Allele Symbol: Dlk1^tm1.2Jvs
• Allele Name: targeted mutation 1.2, Jennifer V Schmidt
• Allele ID: MGI:5471922
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dlk1^tm1.2Jvs/Dlk1^tm1.2Jvs	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5471940
ht2	Dlk1^tm1.2Jvs/Dlk1^+	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5471941

Genotype
MGI:5471940

hm1

• Allelic Composition: Dlk1^tm1.2Jvs/Dlk1^tm1.2Jvs
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal survival ( J:194130 )

• authors state that mice exhibit the same defects as in heterozygotes when the allele is inherited paternally

growth/size/body

decreased body weight ( J:194130 )

• authors state that mice exhibit the same defects as in heterozygotes when the allele is inherited paternally

cellular

maternal imprinting ( J:194130 )

Genotype
MGI:5471941

ht2

• Allelic Composition: Dlk1^tm1.2Jvs/Dlk1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

mortality/aging

mortality/aging ( J:194130 )

N • when the allele is inherited maternally, mice exhibit normal survival

neonatal lethality ( J:194130 )

• when the allele is inherited paternally, some mice die within the first few days after birth

postnatal lethality ( J:194130 )

• when the allele is inherited paternally, some mice die within the first few days after birth

embryo

decreased trophoblast glycogen cell number ( J:194130 )

• decreased number of glycogen cells with an increase in pre-glycogen cells, when the allele is inherited paternally

abnormal placenta labyrinth morphology ( J:194130 )

• increased in cellularity, when the allele is inherited paternally

abnormal placental labyrinth vasculature morphology ( J:194130 )

• decreased vascularity when the allele is inherited paternally

placental labyrinth hypoplasia ( J:194130 )

• reduced size of labyrinth layer when the allele is inherited paternally

growth/size/body

growth/size/body region phenotype ( J:194130 )

N • when the allele is inherited paternally, mice exhibit normal embryonic weight

N • when the allele is inherited maternally, mice exhibit normal growth

decreased body size ( J:194130 )

• dwarfism when the allele is inherited paternally

decreased body weight ( J:194130 )

• from 1 to 6 weeks when the allele is inherited paternally

postnatal growth retardation ( J:194130 )

• when the allele is inherited paternally

adipose tissue

decreased fat cell size ( J:194130 )

• when the allele is inherited paternally at 6, but not 16, weeks

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:194130 )

• decreased vascularity when the allele is inherited paternally