All Phenotypes Tg(Myh6-Gsk3b*)19Jusa MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Myh6-Gsk3b*)19Jusa
transgene insertion 19, Junichi Sadoshima
MGI:5471797

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Myh6-Gsk3b*)19Jusa/0	involves: C57BL/6NCrj * FVB/N	MGI:5471802
tg2	Tg(Myh6-Gsk3b*)19Jusa/0	involves: FVB	MGI:5471803

Allelic Composition	Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Myh6-Gsk3b*)19Jusa/0
Genetic Background	involves: C57BL/6NCrj * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
Tg(Myh6-Gsk3b*)19Jusa mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased myocardial infarct size ( J:186597 )

• following 2 hours of ischemia without reperfusion

• however, treatment with rapamycin reduces infarct size

cellular

abnormal autophagy ( J:186597 )

• reduced autophagy in the heart following 2 hours of ischemia or ischemia with reperfusion

• however, treatment with rapamycin restores autophagy in both cases

homeostasis/metabolism

increased myocardial infarct size ( J:186597 )

• following 2 hours of ischemia without reperfusion

• however, treatment with rapamycin reduces infarct size

abnormal autophagy ( J:186597 )

• reduced autophagy in the heart following 2 hours of ischemia or ischemia with reperfusion

• however, treatment with rapamycin restores autophagy in both cases

Allelic Composition	Tg(Myh6-Gsk3b*)19Jusa/0
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased myocardial infarct size ( J:186597 )

• following ischemia and reperfusion

• however, treatment with rapamycin restores infarct area size

increased myocardial infarct size ( J:186597 )

• following 2 hours of ischemia without reperfusion

homeostasis/metabolism

decreased myocardial infarct size ( J:186597 )

• following ischemia and reperfusion

• however, treatment with rapamycin restores infarct area size

increased myocardial infarct size ( J:186597 )

• following 2 hours of ischemia without reperfusion

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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