Phenotypes associated with this allele

• Allele Symbol: Sptssa^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5471307
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sptssa^tm1b(KOMP)Wtsi/Sptssa^tm1b(KOMP)Wtsi	B6N(Cg)-Sptssa^tm1b(KOMP)Wtsi/J	MGI:6376216
hm2	Sptssa^tm1b(KOMP)Wtsi/Sptssa^tm1b(KOMP)Wtsi	C57BL/6N-Sptssa^tm1b(KOMP)Wtsi/J	MGI:5631585
ht3	Sptssa^tm1b(KOMP)Wtsi/Sptssa^+	C57BL/6N-Sptssa^tm1b(KOMP)Wtsi/J	MGI:5631584

Genotype
MGI:6376216

hm1

• Allelic Composition: Sptssa^{tm1b(KOMP)Wtsi}/Sptssa^{tm1b(KOMP)Wtsi}
• Genetic Background: B6N(Cg)-Sptssa^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0346_5_B07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis ( J:279207 )

• homozygous embryos are recovered at slightly lower Mendelian ratios at E7.5 (20% versus expected 25%) and arrest prior to gastrulation

embryonic lethality, complete penetrance ( J:279207 )

• no homozygous embryos are recovered at E9.5

embryo

failure to gastrulate ( J:279207 )

• no hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no morphological embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

Genotype
MGI:5631585

hm2

• Allelic Composition: Sptssa^{tm1b(KOMP)Wtsi}/Sptssa^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Sptssa^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0346_5_B07

Data Sources

IMPC Data for Sptssa

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:5631584

ht3

• Allelic Composition: Sptssa^{tm1b(KOMP)Wtsi}/Sptssa⁺
• Genetic Background: C57BL/6N-Sptssa^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0346_5_B07

Data Sources

IMPC Data for Sptssa

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

♂

IMPC - JAX

increased circulating sodium level ( J:211773 )

IMPC - JAX