Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm3Spe mutation
(0 available);
any
Runx1 mutation
(35 available)
Slc17a8tm1(cre)Lowl mutation
(0 available);
any
Slc17a8 mutation
(41 available)
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behavior/neurological
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• thermal nociception, chemical nociception, and neuropathic mechanical pain are not markedly affected in mutants
• mechanical allodynia is unaffected in mutants
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• intraplantar injection of carrageenan still induces mechanical hypersensitivity in mutants, but a modest (significant) increase in mechanical thresholds compared to controls is observed (higher magnitude of mechanical stimulus required to evoke paw withdrawal)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm3Spe mutation
(0 available);
any
Runx1 mutation
(35 available)
Slc17a8tm1(cre)Lowl mutation
(0 available);
any
Slc17a8 mutation
(41 available)
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nervous system
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• most sensory neurons innervating hair follicles of the hairy skin display tdTomato +ve unmyelinated circumferential endings in contrast to the longitudinal unmyelinated lanceolate endings observed in control skin; these circumferential endings are located ventral to tdTomato -ve, NF200 +ve myelinated (non-sensory) circumferential endings
• around hairs in the epidermis no decrease in tdTomato +ve free nerve endings is observed; morphology of dermal papillae-epidermis nerve endings in thick glabrous skin is unchanged
• innervation of the touch dome by tdTomato labeled myelinated mechanoreceptors is not changed
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• mutants show a marked loss of mechanosensitive neurons compared to controls, with a concurrent increase in the number of nonsensitive neurons
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• average current density in remaining mechanosensitive small neurons is reduced compared to control mice, but no change in the average current density is detected in medium/large tdTomato-labeled neurons
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Analysis Tools