Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(Hoxa2)Fmr}
• Allele Name: targeted mutation 1, Filippo M Rijli
• Allele ID: MGI:5470285
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(Hoxa2)Fmr/Gt(ROSA)26Sor^+ Olig2^tm2(TVA,cre)Rth/Olig2^+	involves: 129P2/OlaHsd	MGI:5470400

Genotype
MGI:5470400

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Hoxa2)Fmr}/Gt(ROSA)26Sor⁺; Olig2^{tm2(TVA,cre)Rth}/Olig2⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain development ( J:193058 )

• 2-fold decrease in ventral oligodendrogenesis in the prepontine (rhombomere 2- and 3-derived) and pontine (rhombomere 4-derived) territories compared with controls

• however, migration of oligodendrite progenitor cells is normal

decreased oligodendrocyte progenitor number ( J:193058 )

• decrease in ventral oligodendrogenesis in the prepontine (rhombomere 2- and 3-derived) and pontine (rhombomere 4-derived) territories at E13.5 due to reduced proliferation

• however, ventricular progenitors are recovered following additional cell cycle before differentiation

cellular

decreased oligodendrocyte progenitor number ( J:193058 )

• decrease in ventral oligodendrogenesis in the prepontine (rhombomere 2- and 3-derived) and pontine (rhombomere 4-derived) territories at E13.5 due to reduced proliferation

• however, ventricular progenitors are recovered following additional cell cycle before differentiation