Phenotypes associated with this allele

• Allele Symbol: Fendrr^tm1Bgh
• Allele Name: targeted mutation 1, Bernhard G Herrmann
• Allele ID: MGI:5470087
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Fendrr^tm1Bgh/Fendrr^tm2Bgh	involves: 129S6/SvEvTac * C57BL/6	MGI:5470089

Genotype
MGI:5470089

ht1

• Allelic Composition: Fendrr^tm1Bgh/Fendrr^tm2Bgh
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:191565 )

• embryos generated by tetraploid complementation die around E13.75

cardiovascular system

ventricle myocardium hypoplasia ( J:191565 )

• embryos generated by tetraploid complementation display myocardial hypoplasia affecting the ventricular walls and interventricular septum

thin ventricular wall ( J:191565 )

• severe reduction in thickness in embryos generated by tetraploid complementation

poor circulation ( J:191565 )

• embryos generated by tetraploid complementation display accumulation of blood in the right heart chamber at E12.5

• embryos generated by tetraploid complementation display accumulation of fluorescent spheres in the right atrium indicating impaired heart function

decreased fetal cardiomyocyte proliferation ( J:191565 )

• embryos generated by tetraploid complementation display a marked decrease in mitotic cells in the heart at E12.5, but not at E9.5 or E11.5

growth/size/body

omphalocele ( J:191565 )

• embryos generated by tetraploid complementation display prominent omphalocele with parts of the liver and all umbilical vessels protruding from the ventral body

abnormal ventral body wall morphology ( J:191565 )

• embryos generated by tetraploid complementation display a decrease in the thickness of the ventral body wall at E12.5

cellular

decreased fetal cardiomyocyte proliferation ( J:191565 )

• embryos generated by tetraploid complementation display a marked decrease in mitotic cells in the heart at E12.5, but not at E9.5 or E11.5

muscle

ventricle myocardium hypoplasia ( J:191565 )

• embryos generated by tetraploid complementation display myocardial hypoplasia affecting the ventricular walls and interventricular septum

decreased fetal cardiomyocyte proliferation ( J:191565 )

• embryos generated by tetraploid complementation display a marked decrease in mitotic cells in the heart at E12.5, but not at E9.5 or E11.5