Phenotypes associated with this allele

• Allele Symbol: Entpd7^tm1Ktak
• Allele Name: targeted mutation 1, Kiyoshi Takeda
• Allele ID: MGI:5469828
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Entpd7^tm1Ktak/Entpd7^tm1Ktak	B6.Cg-Entpd7^tm1Ktak	MGI:5469830

Genotype
MGI:5469830

hm1

• Allelic Composition: Entpd7^tm1Ktak/Entpd7^tm1Ktak
• Genetic Background: B6.Cg-Entpd7^tm1Ktak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestine physiology ( J:191188 )

• luminal levels of ATP in the small intestine are elevated

• impaired ATP hydrolysing activity in membranes of small intestine epithelial cells

immune system

abnormal CD4-positive, alpha-beta T cell number ( J:191188 )

• large increase in CD4+ cells in the small intestine lamina propria that express Il-17 but not in other lymphoid tissues

• blockade of ATP action severely reduces Th17 T cell numbers

increased T-helper 17 cell number ( J:191188 )

increased susceptibility to experimental autoimmune encephalomyelitis ( J:191188 )

decreased susceptibility to bacterial infection ( J:191188 )

• increased resistance to Citrobacter rodentium infection

hematopoietic system

abnormal CD4-positive, alpha-beta T cell number ( J:191188 )

• large increase in CD4+ cells in the small intestine lamina propria that express Il-17 but not in other lymphoid tissues

• blockade of ATP action severely reduces Th17 T cell numbers

increased T-helper 17 cell number ( J:191188 )