Phenotypes associated with this allele

• Allele Symbol: Arid1a^m1Mag
• Allele Name: mutation 1, Terry Magnuson
• Allele ID: MGI:5469314
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arid1a^m1Mag/Arid1a^m1Mag	involves: 129 * CD-1	MGI:5469317

Genotype
MGI:5469317

hm1

• Allelic Composition: Arid1a^m1Mag/Arid1a^m1Mag
• Genetic Background: involves: 129 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:192829 )

• mice die between E9.5 and E13.5

cardiovascular system

abnormal vascular development ( J:192829 )

• reduced vascular density with minimal branching in the placenta at E10.5

absent myocardial trabeculae ( J:192829 )

• in the ventricles at E9.5 and E10.5

ventricular septal defect ( J:192829 )

• at E10.5

pericardial effusion ( J:192829 )

• beyond E10.5 in some mice

hemorrhage ( J:192829 )

• in the exocoelomic space as early as E9.5

• in the pericardial sac and abdomen of a few mice at E11.5

decreased heart rate ( J:192829 )

• at E10.5, surviving mice exhibit abated pulse rate based on visual inspection compared with wild-type mice

absent heartbeat ( J:192829 )

• in some mice at E9.5

growth/size/body

decreased embryo size ( J:192829 )

• after E8.5

embryo

embryonic growth arrest ( J:192829 )

• between E9.0 and E10.5

decreased embryo size ( J:192829 )

• after E8.5

open neural tube ( J:192829 )

• starting around E9.0 in the hind brain and to a lesser extent the posterior region

abnormal placenta morphology ( J:192829 )

• reduced vascular density with minimal branching in the placenta at E10.5

increased spongiotrophoblast size ( J:192829 )

• thick at late stages

small placenta ( J:192829 )

• despite having large maternal lacunae

abnormal visceral yolk sac morphology ( J:192829 )

• poorly developed with few large vessels and blood loss

pale yolk sac ( J:192829 )

hematopoietic system

hematopoietic system phenotype ( J:192829 )

N • mice exhibit normal primitive hematopoiesis

homeostasis/metabolism

pericardial effusion ( J:192829 )

• beyond E10.5 in some mice

vision/eye

abnormal optic cup morphology ( J:192829 )

• small at E9.5

nervous system

open neural tube ( J:192829 )

• starting around E9.0 in the hind brain and to a lesser extent the posterior region

forebrain hypoplasia ( J:192829 )

• at E9.5

muscle

absent myocardial trabeculae ( J:192829 )

• in the ventricles at E9.5 and E10.5