Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh3gl2tm1Pdc mutation
(1 available);
any
Sh3gl2 mutation
(37 available)
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normal phenotype
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• mice are normal and fertile
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mortality/aging
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• some mice die within 24 hours of birth
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nervous system
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• spontaneous epileptic seizures
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• mossy fiber terminals exhibit reduced numbers of synaptic vesicles and increased clathrin-coated vesicles compared with wild-type mice
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• climbing fibers are thicker and shorter than in wild-type mice
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behavior/neurological
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• spontaneous epileptic seizures
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growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh3gl2tm1Pdc mutation
(1 available);
any
Sh3gl2 mutation
(37 available)
Sh3gl3tm1.2Itl mutation
(0 available);
any
Sh3gl3 mutation
(17 available)
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mortality/aging
N |
• mice survive into adulthood
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mortality/aging
nervous system
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• synapses accumulate clathrin-coated vesicles but not clathrin-coated pits
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• endocytic recovery of synaptic vesicle is 2.5-fold slower than in controls
• however, this defect is rescued by re-expression of Sh3gl1
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• reduction in peak amplitude in response to a single stimulus
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• more than 2.5 times reduction in the frequency and decreased amplitude
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• after a 30 AP at 10, but not 1, Hz stimulus
• recovering is delayed
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respiratory system
behavior/neurological
growth/size/body
behavior/neurological
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• severe epileptic seizures
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nervous system
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• severe epileptic seizures
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