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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dlc1tm1.1Lowy
targeted mutation 1.1, Douglas R Lowy
MGI:5468314
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dlc1tm1.1Lowy/Dlc1tm1.1Lowy involves: 129 * C57BL/6 MGI:5468326
cn2
 		Dlc1tm1.1Lowy/Dlc1tm1.1Lowy involves: 129 * C57BL/6 MGI:5468327


Genotype
MGI:5468326
hm1
Allelic
Composition		 Dlc1tm1.1Lowy/Dlc1tm1.1Lowy
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlc1tm1.1Lowy mutation (0 available); any Dlc1 mutation (227 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:192878 )
• mice are viable and apparently normal




Genotype
MGI:5468327
cn2
Allelic
Composition		 Dlc1tm1.1Lowy/Dlc1tm1.1Lowy
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlc1tm1.1Lowy mutation (0 available); any Dlc1 mutation (227 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:192878 )
• mouse embryonic fibroblasts (MEFs) transfect with a cre-expressing adenovirus and a mutant Ras-expressing adenovirus exhibit enhanced transformation compared with control cells
• however, MEFs transfected with a cre-expressing adenovirus and grown in soft agar do not undergo transformation despite increase in RhoGTP




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory