Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd247tm2.1Lov mutation
(0 available);
any
Cd247 mutation
(11 available)
|
|
|
immune system
|
|
• consistent but not statistically significant
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd247tm2.1Lov mutation
(0 available);
any
Cd247 mutation
(11 available)
|
|
|
immune system
|
N |
• mice do not develop spontaneous autoimmune disease
|
|
|
• depending on the nature of the negative selecting interaction, thymocytes exhibit impaired negative selection compared with control mice
• mice exhibit an increase in regulatory T cell numbers due to increased generation of thymus-derived T regulatory cells
|
|
|
• ex vivo and after in vitro stimulation, CD4+ T cells exhibit significant skewing to Th1 compared with control cell
|
|
|
• in the thymus and periphery
|
|
|
• in the thymus and periphery
|
|
|
• in the thymus, lymph nodes and spleen due to increased generation of thymus-derived T regulatory cells
|
|
|
• mice exhibit increased T cells with memory-like phenotype that proliferate in vivo compared with control mice
• regulatory T cells exhibit enhanced suppressive activity to suppress the proliferation of effector T cells
|
|
|
• double-positive thymocytes are resistant to anti-CD3 and anti-CD28-induced apoptosis compared with control cells
|
|
|
• in the thymus, lymph nodes and spleen due to increased generation of thymus-derived T regulatory cells
|
cellular
|
|
• double-positive thymocytes are resistant to anti-CD3 and anti-CD28-induced apoptosis compared with control cells
|
hematopoietic system
|
|
• depending on the nature of the negative selecting interaction, thymocytes exhibit impaired negative selection compared with control mice
• mice exhibit an increase in regulatory T cell numbers due to increased generation of thymus-derived T regulatory cells
|
|
|
• ex vivo and after in vitro stimulation, CD4+ T cells exhibit significant skewing to Th1 compared with control cell
|
|
|
• in the thymus and periphery
|
|
|
• in the thymus and periphery
|
|
|
• in the thymus, lymph nodes and spleen due to increased generation of thymus-derived T regulatory cells
|
|
|
• mice exhibit increased T cells with memory-like phenotype that proliferate in vivo compared with control mice
• regulatory T cells exhibit enhanced suppressive activity to suppress the proliferation of effector T cells
|
|
|
• double-positive thymocytes are resistant to anti-CD3 and anti-CD28-induced apoptosis compared with control cells
|
|
|
• in the thymus, lymph nodes and spleen due to increased generation of thymus-derived T regulatory cells
|
|
|
• bone marrow cells transplanted into Rag1 null mice induce autoimmune disorder with increased incidence of inflammatory lesions and anti-nuclear antibodies compared when control bone marrow cells are transplanted
• however, mice do not develop spontaneous autoimmune disease
|
endocrine/exocrine glands
|
|
• double-positive thymocytes are resistant to anti-CD3 and anti-CD28-induced apoptosis compared with control cells
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd247tm1Lov mutation
(2 available);
any
Cd247 mutation
(11 available)
Cd247tm2.1Lov mutation
(0 available);
any
Cd247 mutation
(11 available)
|
|
|
immune system
|
N |
• mice do not develop spontaneous autoimmune disease
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd247tm2.1Lov mutation
(0 available);
any
Cd247 mutation
(11 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation
(3 available)
|
|
|
hematopoietic system
|
|
• thymocyte negative selection in response to ubiquitous male antigen is impaired, but not abrogated, compared to in control mice
|
immune system
|
|
• thymocyte negative selection in response to ubiquitous male antigen is impaired, but not abrogated, compared to in control mice
|
Analysis Tools
