All Phenotypes H2-Oa/Brd2<Tg(otx2-lacZ)F5pImat> MGI Mouse

Phenotypes associated with this allele

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:188139 )

• by E13.5

embryo

embryonic growth retardation ( J:188139 )

• in most mice at E10.5

abnormal neural tube morphology ( J:188139 )

• cranial neural tube defects in most mice at E10.5

abnormal embryonic neuroepithelium morphology ( J:188139 )

• severely distorted at the level of the rostral rhombencephalon

abnormal embryonic neuroepithelial layer differentiation ( J:188139 )

• neuroepithelial cells exhibit impaired differentiation with failure to exit the cell cycle compared with wild-type cells

increased embryonic neuroepithelium thickness ( J:188139 )

• irregularly thickened at the level of the rostral rhombencephalon

nervous system

increased embryonic neuroepithelium apoptosis ( J:188139 )

• increased cell death in the neuroepithelium at E10.5

abnormal neural tube morphology ( J:188139 )

• cranial neural tube defects in most mice at E10.5

abnormal embryonic neuroepithelium morphology ( J:188139 )

• severely distorted at the level of the rostral rhombencephalon

abnormal embryonic neuroepithelial layer differentiation ( J:188139 )

• neuroepithelial cells exhibit impaired differentiation with failure to exit the cell cycle compared with wild-type cells

increased embryonic neuroepithelium thickness ( J:188139 )

• irregularly thickened at the level of the rostral rhombencephalon

craniofacial

abnormal craniofacial morphology ( J:188139 )

• in most mice at E10.5

growth/size/body

embryonic growth retardation ( J:188139 )

• in most mice at E10.5

cellular

abnormal cell cycle ( J:188139 )

• neuroepithelial cells exhibit impaired differentiation with failure to exit the cell cycle compared with wild-type cells

increased embryonic neuroepithelium apoptosis ( J:188139 )

• increased cell death in the neuroepithelium at E10.5

Allelic Composition	H2-Oa/Brd2^{Tg(otx2-lacZ)F5pImat}/H2-Oa/Brd2^{Tg(otx2-lacZ)F5pImat} E2f1^tm1Meg/E2f1^tm1Meg
Genetic Background	involves: 129S4/SvJae * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1^tm1Meg mutation (2 available); any E2f1 mutation (25 available)
H2-Oa/Brd2^{Tg(otx2-lacZ)F5pImat} mutation (0 available); any Brd2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:188139 )

N	• mice exhibit normal neurulation and neuroepithelial development with rescue of cell death

nervous system

nervous system phenotype ( J:188139 )

N	• mice exhibit normal neurulation and neuroepithelial development with rescue of cell death

Allelic Composition	H2-Oa/Brd2^{Tg(otx2-lacZ)F5pImat}/H2-Oa/Brd2^{Tg(otx2-lacZ)F5pImat} Tg(CAG-Brd2,-EGFP)#Imat/0
Genetic Background	involves: CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Oa/Brd2^{Tg(otx2-lacZ)F5pImat} mutation (0 available); any Brd2 mutation (43 available)
Tg(CAG-Brd2,-EGFP)#Imat mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:188139 )

N	• mice develop normally

Allelic Composition	H2-Oa/Brd2^{Tg(otx2-lacZ)F5pImat}/H2-Oa/Brd2^{Tg(otx2-lacZ)F5pImat} Tg(CAG-EGFP/Brd2)#Imat/0
Genetic Background	involves: CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:188139 )

• mice are viable and fertile

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