Phenotypes associated with this allele

• Allele Symbol: Sp7^tm1.1Rnis
• Allele Name: targeted mutation 1.1, Riko Nishimura
• Allele ID: MGI:5466596
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sp7^tm1.1Rnis/Sp7^tm1.1Rnis	involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA	MGI:5466670
cx2	Sp7^tm1.1Rnis/Sp7^+ Zfhx4^tm1.1Rnis/Zfhx4^tm1.1Rnis	involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA	MGI:7344366

Genotype
MGI:5466670

hm1

• Allelic Composition: Sp7^tm1.1Rnis/Sp7^tm1.1Rnis
• Genetic Background: involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Impaired ossification and matrix vesicle formation in Sp7^tm1.1Rnis/Sp7^tm1.1Rnis mice

skeleton

abnormal skeleton development ( J:191589 )

• BMP2 treatment fails to cause calcification in the limb bud cells unlike control cells

failure of bone ossification ( J:191589 )

• no ossification of the ribs, limbs and vertebrae at E15.5

• ossification of fore and hind limbs is inhibited at E18.5

failure of endochondral bone ossification ( J:191589 )

• endochondral ossification stopped at the hypertrophic stage

Genotype
MGI:7344366

cx2

• Allelic Composition: Sp7^tm1.1Rnis/Sp7⁺; Zfhx4^tm1.1Rnis/Zfhx4^tm1.1Rnis
• Genetic Background: involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA

skeleton

decreased chondrocyte number ( J:316165 )

• decrease in the number of hypertrophic chondrocytes at E16.5 that is more sever compared to mutant mice wild-type for Sp7

abnormal endochondral bone ossification ( J:316165 )

• impairment of calcification of the femur is more sever at E16.5 compared to mutant mice wild-type for Sp7