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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cthrc1tm1Vli
targeted mutation 1, Volkhard Lindner
MGI:5466394
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cthrc1tm1Vli/Cthrc1tm1Vli 129S6.Cg-Cthrc1tm1Vli MGI:5466396
hm2
 		Cthrc1tm1Vli/Cthrc1tm1Vli B6.Cg-Cthrc1tm1Vli MGI:5466395


Genotype
MGI:5466396
hm1
Allelic
Composition		 Cthrc1tm1Vli/Cthrc1tm1Vli
Genetic
Background		 129S6.Cg-Cthrc1tm1Vli
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cthrc1tm1Vli mutation (0 available); any Cthrc1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating glucose level ( J:192096 )
• after insulin administration
insulin resistance ( J:192096 )
• slightly

liver/biliary system

muscle




Genotype
MGI:5466395
hm2
Allelic
Composition		 Cthrc1tm1Vli/Cthrc1tm1Vli
Genetic
Background		 B6.Cg-Cthrc1tm1Vli
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cthrc1tm1Vli mutation (0 available); any Cthrc1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Fatty liver in Cthrc1tm1Vli/Cthrc1tm1Vli mice

liver/biliary system
abnormal hepatocyte morphology ( J:192096 )
• increased cell size
liver hypoplasia ( J:192096 )
• lower cell density without a change in liver weight




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory