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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Cd4-cre/ERT2)11Gnri
transgene insertion 11, Fotini Gounari
MGI:5464279
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nup210tm1Mdan/Nup210tm1Mdan
Tg(Cd4-cre/ERT2)11Gnri/0 		involves: 129X1/SvJ * C57BL/6 MGI:6830956
cn2
 		Rhoatm1.1Tpal/Rhoa+
Tg(Cd4-cre/ERT2)11Gnri/0 		involves: C57BL/6 MGI:6401219


Genotype
MGI:6830956
cn1
Allelic
Composition		 Nup210tm1Mdan/Nup210tm1Mdan
Tg(Cd4-cre/ERT2)11Gnri/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup210tm1Mdan mutation (0 available); any Nup210 mutation (85 available)
Tg(Cd4-cre/ERT2)11Gnri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:282451 )
• cell-intrinsic reduction in naive CD4+ T cell survival in the periphery in tamoxifen-treated mice

immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:282451 )
• cell-intrinsic reduction in naive CD4+ T cell survival in the periphery in tamoxifen-treated mice




Genotype
MGI:6401219
cn2
Allelic
Composition		 Rhoatm1.1Tpal/Rhoa+
Tg(Cd4-cre/ERT2)11Gnri/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhoatm1.1Tpal mutation (0 available); any Rhoa mutation (70 available)
Tg(Cd4-cre/ERT2)11Gnri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:257764 )
• CD4+ T cells from tamoxifen-treated mice show increased proliferation when stimulated with anti-CD3 plus anti-CD28 antibodies and with anti-CD3 antibody in the presence of iAPCs
increased T follicular helper cell number ( J:257764 )
• tamoxifen-treated non-immunized mice show increased numbers of CXCR5+ PD1+ T follicular helper cells (Tfh) cells and BCL6+ CXCR5+ Tfh cells indicating induction of Tfh cell polarization
increased regulatory T cell number ( J:257764 )
• tamoxifen-treated non-immunized mice show increased numbers of FOXP3+ CD25+ T regulatory (Treg) cells and FOXP3+ CXCR5+ T follicular helper regulatory cells (Tfr)
• however, differentiation of IFNG+ T helper 1 cells is not affected upon tamoxifen-treatment and generation of CD4+ and CD8+ cells in the thymus is unaffected

hematopoietic system
increased T cell proliferation ( J:257764 )
• CD4+ T cells from tamoxifen-treated mice show increased proliferation when stimulated with anti-CD3 plus anti-CD28 antibodies and with anti-CD3 antibody in the presence of iAPCs
increased T follicular helper cell number ( J:257764 )
• tamoxifen-treated non-immunized mice show increased numbers of CXCR5+ PD1+ T follicular helper cells (Tfh) cells and BCL6+ CXCR5+ Tfh cells indicating induction of Tfh cell polarization
increased regulatory T cell number ( J:257764 )
• tamoxifen-treated non-immunized mice show increased numbers of FOXP3+ CD25+ T regulatory (Treg) cells and FOXP3+ CXCR5+ T follicular helper regulatory cells (Tfr)
• however, differentiation of IFNG+ T helper 1 cells is not affected upon tamoxifen-treatment and generation of CD4+ and CD8+ cells in the thymus is unaffected

cellular
increased T cell proliferation ( J:257764 )
• CD4+ T cells from tamoxifen-treated mice show increased proliferation when stimulated with anti-CD3 plus anti-CD28 antibodies and with anti-CD3 antibody in the presence of iAPCs




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory