Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Cd4-cre/ERT2)11Gnri transgene insertion 11, Fotini Gounari MGI:5464279 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cell-intrinsic reduction in naive CD4+ T cell survival in the periphery in tamoxifen-treated mice
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• cell-intrinsic reduction in naive CD4+ T cell survival in the periphery in tamoxifen-treated mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CD4+ T cells from tamoxifen-treated mice show increased proliferation when stimulated with anti-CD3 plus anti-CD28 antibodies and with anti-CD3 antibody in the presence of iAPCs
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• tamoxifen-treated non-immunized mice show increased numbers of CXCR5+ PD1+ T follicular helper cells (Tfh) cells and BCL6+ CXCR5+ Tfh cells indicating induction of Tfh cell polarization
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• tamoxifen-treated non-immunized mice show increased numbers of FOXP3+ CD25+ T regulatory (Treg) cells and FOXP3+ CXCR5+ T follicular helper regulatory cells (Tfr)
• however, differentiation of IFNG+ T helper 1 cells is not affected upon tamoxifen-treatment and generation of CD4+ and CD8+ cells in the thymus is unaffected
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• CD4+ T cells from tamoxifen-treated mice show increased proliferation when stimulated with anti-CD3 plus anti-CD28 antibodies and with anti-CD3 antibody in the presence of iAPCs
|
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• tamoxifen-treated non-immunized mice show increased numbers of CXCR5+ PD1+ T follicular helper cells (Tfh) cells and BCL6+ CXCR5+ Tfh cells indicating induction of Tfh cell polarization
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• tamoxifen-treated non-immunized mice show increased numbers of FOXP3+ CD25+ T regulatory (Treg) cells and FOXP3+ CXCR5+ T follicular helper regulatory cells (Tfr)
• however, differentiation of IFNG+ T helper 1 cells is not affected upon tamoxifen-treatment and generation of CD4+ and CD8+ cells in the thymus is unaffected
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• CD4+ T cells from tamoxifen-treated mice show increased proliferation when stimulated with anti-CD3 plus anti-CD28 antibodies and with anti-CD3 antibody in the presence of iAPCs
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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