Phenotypes associated with this allele

• Allele Symbol: Htr1b^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5463939
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Htr1b^tm1.1(KOMP)Vlcg/Htr1b^tm1.1(KOMP)Vlcg	C57BL/6N-Htr1b^tm1.1(KOMP)Vlcg/J	MGI:5631211
hm2	Htr1b^tm1.1(KOMP)Vlcg/Htr1b^tm1.1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:6400804
ht3	Htr1b^tm1.1(KOMP)Vlcg/Htr1b^+	C57BL/6N-Htr1b^tm1.1(KOMP)Vlcg/J	MGI:5631210

Genotype
MGI:5631211

hm1

• Allelic Composition: Htr1b^{tm1.1(KOMP)Vlcg}/Htr1b^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Htr1b^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 13007A-F5

Data Sources

IMPC Data for Htr1b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6400804

hm2

• Allelic Composition: Htr1b^{tm1.1(KOMP)Vlcg}/Htr1b^{tm1.1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:284574 )

N • P0 beta cell proliferation is normal

Genotype
MGI:5631210

ht3

• Allelic Composition: Htr1b^{tm1.1(KOMP)Vlcg}/Htr1b⁺
• Genetic Background: C57BL/6N-Htr1b^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 13007A-F5

Data Sources

IMPC Data for Htr1b

adipose tissue

decreased total body fat amount ( J:211773 )

♂

IMPC - JAX

behavior/neurological

decreased grip strength ( J:211773 )

♂

IMPC - JAX

hyperactivity ( J:211773 )

IMPC - JAX

cardiovascular system

increased heart weight ( J:211773 )

IMPC - JAX

growth/size/body

increased heart weight ( J:211773 )

IMPC - JAX

increased lean body mass ( J:211773 )

♂

IMPC - JAX