Phenotypes associated with this allele

• Allele Symbol: Tg(Rp1)L2Eap
• Allele Name: transgene insertion L2, Eric A Pierce
• Allele ID: MGI:5463931
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Rp1^tm2.1Eap/Rp1^tm2.1Eap Tg(Rp1)L2Eap/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:5463942
tg2	Tg(Rp1)L2Eap/0	involves: C57BL/6	MGI:5463944

Genotype
MGI:5463942

cx1

• Allelic Composition: Rp1^tm2.1Eap/Rp1^tm2.1Eap; Tg(Rp1)L2Eap/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina neuronal layer morphology ( J:191685 )

• mixed normal and disorganized discs

• some aberrant structures at 2 months of age

short photoreceptor outer segment ( J:191685 )

• shorter outer segments at 2 and 12 months of age

retina degeneration ( J:191685 )

• some retinal degeneration at 12 months of age

abnormal rod electrophysiology ( J:191685 )

• rod a-waves in ERG at 17% normal at 12 months of age

nervous system

short photoreceptor outer segment ( J:191685 )

• shorter outer segments at 2 and 12 months of age

Genotype
MGI:5463944

tg2

• Allelic Composition: Tg(Rp1)L2Eap/0
• Genetic Background: involves: C57BL/6

vision/eye

vision/eye phenotype ( J:191685 )

N • histology of photoreceptors well preserved to 1 year of age

N • normal retinal function by ERG to 1 year of age