About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atmtm1Shzh
targeted mutation 1, Shan Zha
MGI:5463796
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Atmtm1Shzh/Atmtm2.1Fwa involves: 129S6/SvEvTac MGI:5463806
cn2
 		Atmtm1Shzh/Atmtm2.1Fwa
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+ 		involves: 129 * 129S6/SvEvTac MGI:5463807


Genotype
MGI:5463806
cn1
Allelic
Composition		 Atmtm1Shzh/Atmtm2.1Fwa
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Shzh mutation (0 available); any Atm mutation (168 available)
Atmtm2.1Fwa mutation (2 available); any Atm mutation (168 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:191288 )
• embryonic stem cells infected with a cre-expressing adenovirus exhibit increased genomic instability (breaks in one or both sister chromatids) compared with wild-type and Atmtm1Fwa cells




Genotype
MGI:5463807
cn2
Allelic
Composition		 Atmtm1Shzh/Atmtm2.1Fwa
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129 * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Shzh mutation (0 available); any Atm mutation (168 available)
Atmtm2.1Fwa mutation (2 available); any Atm mutation (168 available)
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:191288 )
• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atmtm1Fwa cells

immune system
abnormal class switch recombination ( J:191288 )
• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atmtm1Fwa cells

hematopoietic system
abnormal class switch recombination ( J:191288 )
• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atmtm1Fwa cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory