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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atmtm1Shzh
targeted mutation 1, Shan Zha
MGI:5463796
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Atmtm1Shzh/Atmtm2.1Fwa involves: 129S6/SvEvTac MGI:5463806
cn2
 		Atmtm1Shzh/Atmtm2.1Fwa
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+ 		involves: 129 * 129S6/SvEvTac MGI:5463807


Genotype
MGI:5463806
cn1
Allelic
Composition		 Atmtm1Shzh/Atmtm2.1Fwa
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Shzh mutation (0 available); any Atm mutation (169 available)
Atmtm2.1Fwa mutation (2 available); any Atm mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:191288 )
• embryonic stem cells infected with a cre-expressing adenovirus exhibit increased genomic instability (breaks in one or both sister chromatids) compared with wild-type and Atmtm1Fwa cells




Genotype
MGI:5463807
cn2
Allelic
Composition		 Atmtm1Shzh/Atmtm2.1Fwa
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129 * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Shzh mutation (0 available); any Atm mutation (169 available)
Atmtm2.1Fwa mutation (2 available); any Atm mutation (169 available)
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:191288 )
• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atmtm1Fwa cells

immune system
abnormal class switch recombination ( J:191288 )
• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atmtm1Fwa cells

hematopoietic system
abnormal class switch recombination ( J:191288 )
• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atmtm1Fwa cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory