Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-Vtcn1)#Xxz
• Allele Name: transgene insertion, Xingxing Zang
• Allele ID: MGI:5463744
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	H2^g7/H2^g7 Tg(Ins2-Vtcn1)#Xxz/0 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0	involves: C57BL/6 * NOD * SJL	MGI:5463746

Genotype
MGI:5463746

cx1

• Allelic Composition: H2^g7/H2^g7; Tg(Ins2-Vtcn1)#Xxz/0; Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
• Genetic Background: involves: C57BL/6 * NOD * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased regulatory T cell number ( J:177612 )

• in the pancreas

decreased interferon-gamma secretion ( J:177612 )

• from CD4+ pancreatic T cells

decreased interleukin-17 secretion ( J:177612 )

• from CD4+ pancreatic T cells

decreased susceptibility to autoimmune diabetes ( J:177612 )

• diabetes disease progression is abrogated compared to in control mice

• however, mice develop insulitis

hematopoietic system

decreased regulatory T cell number ( J:177612 )

• in the pancreas