Phenotypes associated with this allele

• Allele Symbol: Arih2^tm1Mak
• Allele Name: targeted mutation 1, Tak Mak
• Allele ID: MGI:5463664
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arih2^tm1Mak/Arih2^tm1Mak	B6.129P2-Arih2^tm1Mak	MGI:5463666
hm2	Arih2^tm1Mak/Arih2^tm1Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:5463665
cx3	Arih2^tm1Mak/Arih2^tm1Mak Myd88^tm1Aki/Myd88^tm1Aki	involves: 129P2/OlaHsd * C57BL/6	MGI:5463667

Genotype
MGI:5463666

hm1

• Allelic Composition: Arih2^tm1Mak/Arih2^tm1Mak
• Genetic Background: B6.129P2-Arih2^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:191066 )

• Background Sensitivity: on an inbred C57BL/6 background mice die at E16.5, unlike mice on a mixed 129P2/OlaHsd and C57BL/6 background that display postnatal lethality

immune system

abnormal dendritic cell physiology ( J:191066 )

• dendritic cells spuriously and spontaneously activate in culture

increased inflammatory response ( J:191066 )

• when hematopoietic progenitor cells are transferred into lethally irradiated Rag1^tm1Mom mice, the mice develop a spontaneous lethal inflammation

liver/biliary system

liver hypoplasia ( J:191066 )

abnormal liver physiology ( J:191066 )

• abundant apoptosis is detected in the liver at E16.5

• however, the hematopoietic progenitor compartment of the fetal liver is relatively unaffected

cellular

increased apoptosis ( J:191066 )

• abundant apoptosis is detected in the liver at E16.5

Genotype
MGI:5463665

hm2

• Allelic Composition: Arih2^tm1Mak/Arih2^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

postnatal lethality, incomplete penetrance ( J:191066 )

• Background Sensitivity: on a mixed 129P2/OlaHsd and C57BL/6 background pups are born alive but most die in the first week of life with only 3.3% surviving at 3 weeks of age, in contrast on an inbred C57BL/6 background no live births are seen

immune system

increased inflammatory response ( J:191066 )

• survivors display overt inflammatory phenotypes

• infiltration of T cells, macrophages, granulocytes and dendritic cells in various organs, including liver, lung and heart

heart inflammation ( J:191066 )

• infiltration of T cells, macrophages, granulocytes and dendritic cells

liver inflammation ( J:191066 )

• infiltration of T cells, macrophages, granulocytes and dendritic cells

lung inflammation ( J:191066 )

• infiltration of T cells, macrophages, granulocytes and dendritic cells

dermatitis ( J:191066 )

• debilitating dermatitis is seen in survivors

growth/size/body

decreased body size ( J:191066 )

• survivors are severely runted

cachexia ( J:191066 )

integument

dermatitis ( J:191066 )

• debilitating dermatitis is seen in survivors

liver/biliary system

liver inflammation ( J:191066 )

• infiltration of T cells, macrophages, granulocytes and dendritic cells

cardiovascular system

heart inflammation ( J:191066 )

• infiltration of T cells, macrophages, granulocytes and dendritic cells

respiratory system

lung inflammation ( J:191066 )

• infiltration of T cells, macrophages, granulocytes and dendritic cells

Genotype
MGI:5463667

cx3

• Allelic Composition: Arih2^tm1Mak/Arih2^tm1Mak; Myd88^tm1Aki/Myd88^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

abnormal survival ( J:191066 )

• survival is prolonged compared to mutant mice wild-type for Myd88