Phenotypes associated with this allele
Allelic Composition |
Fras1bfb/Fras1bfb
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Genetic Background |
involves: C3H/HeH * C57BL/6JAnu |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fras1bfb mutation
(1 available);
any
Fras1 mutation
(216 available)
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Craniofacial and skeletal mutants: (A-D) Fras1bfb, (E-G) Ift140cauli, (H-J) knyn, and (K-M) Crklsnoopy homozygotes
craniofacial
vision/eye
integument
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• blood filled blisters on the head and feet at E13.5
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limbs/digits/tail
renal/urinary system
digestive/alimentary system
growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fras1bfb mutation
(1 available);
any
Fras1 mutation
(216 available)
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Blood-filled blisters across the eye and the distal hindlimbs in Fras1bfb/Fras1bfb embryos
craniofacial
N |
• mice do not exhibit cleft of the lip and/or primary palate
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• delayed palatal shelf growth at E14.5
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• formation of a blister-like structure between the palatal shelves and nasal septum in mice without over cleft palate at E15.5
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• in some mice at E18.5
• complete in the majority of cases; partial in remaining cases
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skeleton
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• second and fifth sternebrae are bipartite resulting in misalignment of corresponding ribs in most mice
• however, the first and last sternebrae appear normal
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• second and fifth sternebrae are bipartite resulting in misalignment of corresponding ribs in most mice
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integument
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• residual pooling of blood under the skin at E18.5
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• clear fluid-filled blisters over the lateral aspects of the head at E12.5, prominent at E15.5
• blood-filled blisters over the eyes at E13.5
• clear fluid-filled blisters on the distal hindlimbs at E13.5 that become hemorrhagic and localized to the distal region of the hind feet and often involves the toes at E15.5
• however, by E18.5 blisters are typically resolved and forelimbs never present with hemorrhagic blisters
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renal/urinary system
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• absent or severely reduced in most mice
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• absent or severely reduced in most mice
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vision/eye
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• absence of palpebral fissure in most mice after E15.5
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cardiovascular system
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• residual pooling of blood under the skin at E18.5
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limbs/digits/tail
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• in the hindlimbs
• however, forelimbs never present with digit anomalies
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digestive/alimentary system
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• delayed palatal shelf growth at E14.5
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• formation of a blister-like structure between the palatal shelves and nasal septum in mice without over cleft palate at E15.5
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• in some mice at E18.5
• complete in the majority of cases; partial in remaining cases
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growth/size/body
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• delayed palatal shelf growth at E14.5
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• formation of a blister-like structure between the palatal shelves and nasal septum in mice without over cleft palate at E15.5
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• in some mice at E18.5
• complete in the majority of cases; partial in remaining cases
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