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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vdrtm1.2Sgcg
targeted mutation 1.2, Songcang Chen
MGI:5461525
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Vdrtm1.2Sgcg/Vdrtm1.2Sgcg involves: 129 * C57BL/6 * CBA * SJL MGI:5461534
cn2
 		Vdrtm1.1Sgcg/Vdrtm1.2Sgcg
Myl2tm1(cre)Krc/Myl2+ 		involves: 129 * C57BL/6 * CBA * SJL MGI:5461535


Genotype
MGI:5461534
hm1
Allelic
Composition		 Vdrtm1.2Sgcg/Vdrtm1.2Sgcg
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vdrtm1.2Sgcg mutation (0 available); any Vdr mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism

endocrine/exocrine glands

cardiovascular system

growth/size/body
decreased body weight ( J:189471 )

integument




Genotype
MGI:5461535
cn2
Allelic
Composition		 Vdrtm1.1Sgcg/Vdrtm1.2Sgcg
Myl2tm1(cre)Krc/Myl2+
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl2tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)
Vdrtm1.1Sgcg mutation (0 available); any Vdr mutation (35 available)
Vdrtm1.2Sgcg mutation (0 available); any Vdr mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:189471 )
N
• untreated and isoflurane-treated mice exhibit normal left ventricular systolic and diastolic function
increased myocardial fiber size ( J:189471 )
• in untreated and isoflurane-treated mice
cardiac hypertrophy ( J:189471 )
• in untreated and isoflurane-treated mice
abnormal heart ventricle morphology ( J:189471 )
• untreated and isoflurane-treated mice exhibit a reduction in end-diastolic volume and end-systolic volume compared with control mice
thick interventricular septum ( J:189471 )
• in untreated and isoflurane-treated mice
increased heart left ventricle weight ( J:189471 )
• in untreated and isoflurane-treated mice
thick ventricular wall ( J:189471 )
• untreated and isoflurane-treated mice exhibit increased thickness of the posterior left ventricular free wall compared with control mice

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:189471 )
N
• unlike null homozygotes, mice are not hypocalcemic

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:189471 )
N
• unlike null homozygotes, mice do not develop hyperparathyroidism

muscle
increased myocardial fiber size ( J:189471 )
• in untreated and isoflurane-treated mice

growth/size/body
cardiac hypertrophy ( J:189471 )
• in untreated and isoflurane-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory