All Phenotypes Rest<tm1.2Yasu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rest^tm1.2Yasu
targeted mutation 1.2, Yasuhiro Yamada
MGI:5450876

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rest^tm1.1Yasu/Rest^tm1.2Yasu Alpl^tm1(cre)Nagy/Alpl⁺	involves: 129 * C57BL/6 * C57BL/6J	MGI:5450879

Allelic Composition	Rest^tm1.1Yasu/Rest^tm1.2Yasu Alpl^tm1(cre)Nagy/Alpl⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpl^tm1(cre)Nagy mutation (6 available); any Alpl mutation (351 available)
Rest^tm1.1Yasu mutation (1 available); any Rest mutation (95 available)
Rest^tm1.2Yasu mutation (0 available); any Rest mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:190948 )

N	• despite the decrease in primordial germ cell numbers, germ cell numbers at E18.5 and fertility of adult mice are similar to wild-type controls

decreased primordial germ cell number ( J:190948 )

• at E12.5 in the genital ridge

increased primordial germ cell apoptosis ( J:190948 )

• increase in the ratio of apoptotic to viable PGCs at E11.5

cellular

decreased primordial germ cell number ( J:190948 )

• at E12.5 in the genital ridge

increased primordial germ cell apoptosis ( J:190948 )

• increase in the ratio of apoptotic to viable PGCs at E11.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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