Phenotypes associated with this allele

• Allele Symbol: Del(7Cyp2s1-Cyp2a5)1Ding
• Allele Name: deletion, Chr 7, Xinxin Ding 1
• Allele ID: MGI:5449923
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(7Cyp2s1-Cyp2a5)1Ding/Del(7Cyp2s1-Cyp2a5)1Ding	involves: BALB/cJ * C57BL/6	MGI:5449927

Genotype
MGI:5449927

hm1

• Allelic Composition: Del(7Cyp2s1-Cyp2a5)1Ding/Del(7Cyp2s1-Cyp2a5)1Ding
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:190445 )

• rates of testosterone metabolism are reduced in the liver, lung, nasal olfactory mucosa and brain

behavior/neurological

enhanced behavioral response to anesthetic ( J:190445 )

• the sleep time induced by i.p. 60 mg/kg pentobarbital is significantly longer than in controls suggesting a defect in pentobarbital clearance

liver/biliary system

abnormal liver physiology ( J:190445 )

• decrease in the rate of testosterone metabolism with a 50% decrease in the rate of formation of 15Beta-OH-T

nervous system

abnormal nervous system physiology ( J:190445 )

• decrease in the rate of testosterone metabolism with a 40% decrease in the rate of production of 16alpha-OH-T

respiratory system

abnormal respiratory system physiology ( J:190445 )

• all three major metabolites of testosterone are barely detectable in the lung and nasal olfactory mucosa