All Phenotypes Il2<tm1.1Kasm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il2^tm1.1Kasm
targeted mutation 1.1, Kendall A Smith
MGI:5449713

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Il2^tm1.1Kasm/Il2^tm1.1Kasm Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/?	involves: 129S/SvEv * C57BL/6	MGI:5449733

Allelic Composition	Il2^tm1.1Kasm/Il2^tm1.1Kasm Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/?
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2^tm1.1Kasm mutation (1 available); any Il2 mutation (41 available)
Ndor1^{Tg(UBC-cre/ERT2)1Ejb} mutation (6 available); any Ndor1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:190168 )

N	• normal increase in size and granularity of both CD4+ and CD8+ T cells after 5 days of tamoxifen treatment and activation with anti-CD3/28 • also normal increase in DNA replication in activated CD4+ and CD8+ T cells after 5 days of tamoxifen treatment and activation with anti-CD3/28

decreased circulating interleukin-17 level ( J:190168 )

• after 5 days of tamoxifen treatment and activation with anti-CD3/28

cellular

abnormal cellular respiration ( J:190168 )

• fail to switch from oxidative phosphorylation to aerobic glycolysis after 5 days of tamoxifen treatment and activation with anti-CD3/28

homeostasis/metabolism

decreased circulating interleukin-17 level ( J:190168 )

• after 5 days of tamoxifen treatment and activation with anti-CD3/28

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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