Phenotypes associated with this allele

• Allele Symbol: Ppp1r13l^woe2
• Allele Name: waved with open eyelids 2
• Allele ID: MGI:5449625
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp1r13l^woe2/Ppp1r13l^woe2	involves: 129X1/SvJ * C57BL/6	MGI:5449631

Genotype
MGI:5449631

hm1

• Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Wavy coat and mineralized foci and plaques in hearts of Ppp1r13l^woe2/Ppp1r13l^woe2 mice

mortality/aging

premature death ( J:190557 )

• mice live on average until around 9 months of age

vision/eye

abnormal iris morphology ( J:190557 )

• disorganized at P28

anterior iris synechia ( J:190557 )

abnormal conjunctival sac morphology ( J:190557 )

• lack of conjunctival sacs

abnormal cornea morphology ( J:190557 )

• hyperplastic and disorganized

cornea vascularization ( J:190557 )

• at P28

cornea opacity ( J:190557 )

• at P28

aphakia ( J:190557 )

microphthalmia ( J:190557 )

• severe

abnormal eyelid morphology ( J:190557 )

• at P28, 25% of mice exhibit unilateral or bilateral eyelid closure unlike wild-type mice

absent Meibomian glands ( J:190557 )

• at P28

failure of eyelid fusion ( J:190557 )

• at E16.5

eyelids open at birth ( J:190557 )

abnormal retina morphology ( J:190557 )

• disorganized at P28

cardiovascular system

abnormal heart morphology ( J:190557 )

• adult mice exhibit focal opaque white plaques, which tend to occur in myocardium adjacent to the epicardium or in the interventricular septum, unlike in wild-type mice

abnormal myocardium layer morphology ( J:190557 )

• with focal opaque white plaques in myocardium adjacent to the epicardium

abnormal interventricular septum morphology ( J:190557 )

• with focal opaque white plaques

cornea vascularization ( J:190557 )

• at P28

integument

absent Meibomian glands ( J:190557 )

• at P28

waved hair ( J:190557 )

• beginning around P14 and remaining throughout life

hyperkeratosis ( J:190557 )

• hyperkeratosis of the eyelids

• stromal keratitis

endocrine/exocrine glands

absent Meibomian glands ( J:190557 )

• at P28

muscle

abnormal myocardium layer morphology ( J:190557 )

• with focal opaque white plaques in myocardium adjacent to the epicardium