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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Epcamtm1.2Hmd
targeted mutation 1.2, Hiroshi Hamada
MGI:5449522
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Epcamtm1.2Hmd/Epcamtm1.2Hmd involves: 129 * C57BL/6 MGI:5449525


Genotype
MGI:5449525
hm1
Allelic
Composition		 Epcamtm1.2Hmd/Epcamtm1.2Hmd
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epcamtm1.2Hmd mutation (1 available); any Epcam mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality during fetal growth through weaning, incomplete penetrance ( J:190580 )
• most mice die within 10 days of birth
• fewer than expected mice are produced from breeding heterozygous mice

digestive/alimentary system
abnormal intestine physiology ( J:190580 )
• impaired barrier function in the intestinal epithelium and tight junction structural anomalies




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory