Phenotypes associated with this allele

• Allele Symbol: Kdm6a^tm2.1Kaig
• Allele Name: targeted mutation 2.1, Kai Ge
• Allele ID: MGI:5448826
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdm6a^tm2.1Kaig/Kdm6a^tm2.1Kaig	involves: 129S4/SvJae * C57BL/6	MGI:5779972
ht2	Kdm6a^tm2.1Kaig/Kdm6a^Gt(RRA094)Byg	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:8363226
ot3	Kdm6a^tm2.1Kaig/Y	involves: 129S4/SvJae * C57BL/6	MGI:5779971

Genotype
MGI:5779972

hm1

• Allelic Composition: Kdm6a^tm2.1Kaig/Kdm6a^tm2.1Kaig
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

craniofacial phenotype ( J:249358 )

♀N • females have normal facial characteristics, with normal facial angular measurements at early postnatal timepoints

muscle

muscle phenotype ( J:232700 )

♀N • mice exhibit normal myofiber integrity

abnormal muscle precursor cell morphology ( J:232700 )

♀ • muscle progenitor cells fail to differentiate ex vitro

impaired skeletal muscle regeneration ( J:232700 )

♀ • following CTX-induced muscle injury

growth/size/body

growth/size/body region phenotype ( J:249358 )

♀N • mice have normal body weight

Genotype
MGI:8363226

ht2

• Allelic Composition: Kdm6a^tm2.1Kaig/Kdm6a^{Gt(RRA094)Byg}
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

craniofacial

abnormal snout morphology ( J:249358 )

♀ • females display mild snout depression

growth/size/body

abnormal snout morphology ( J:249358 )

♀ • females display mild snout depression

Genotype
MGI:5779971

ot3

• Allelic Composition: Kdm6a^tm2.1Kaig/Y
• Genetic Background: involves: 129S4/SvJae * C57BL/6

muscle

muscle phenotype ( J:232700 )

♂N • mice exhibit normal myofiber integrity

abnormal muscle precursor cell morphology ( J:232700 )

♂ • muscle progenitor cells fail to differentiate ex vitro

impaired skeletal muscle regeneration ( J:232700 )

♂ • following CTX-induced muscle injury